e-Drug3D
1205
cas 144598-75-4
CLASS
NERVOUS SYSTEM
ANTIPSYCHOTIC
SCHIZOPHRENIA
BENZISOXAZOLE DERIVATIVES
DOPAMINE D2 RECEPTOR ANTAGONIST
SEROTONIN TYPE 2 (5HT2A) RECEPTOR ANTAGONIST
ROUTE (list)
ORAL
ATC code
N05AX13
PK parameters
Tmax 3 HOUR
VD 391 LITER
Cl 10.8 LITER / HOUR (EQN)
PPB 74 PERCENT
t1/2 25 HOUR
Solubility
PRACTICALLY INSOLUBLE IN WATER
TARGET 5-HYDROXYTRYPTAMINE 2A RECEPTOR
D(2) DOPAMINE RECEPTOR
ALPHA1 ADRENERGIC RECEPTOR
ALPHA2 ADRENERGIC RECEPTOR
H1 HISTAMINERGIC RECEPTOR
D(2) DOPAMINE RECEPTOR
ALPHA1 ADRENERGIC RECEPTOR
ALPHA2 ADRENERGIC RECEPTOR
H1 HISTAMINERGIC RECEPTOR
PDB
8GSQ (STRUCTURE BASED STUDIES REVEAL AN ATYPICAL ANTIPSYCHOTIC DRUG CANDIDATE - PALIPERIDONE AS A POTENT HSOD1 MODULATOR WITH IMPLICATIONS IN ALS TREATMENT)
Ligand code = K4I (link to the list of PDB complexes)
Download experimental 3D coordinates of K4I with added hydrogens
D(2) dopamine receptor UNIPROT P14416 DRD2
5-hydroxytryptamine receptor 2A UNIPROT P28223 HTR2A
Formula:
C23H27FN4O3
Calculated chemical properties:
MW 426.49
NB_atoms 31
XLogP 3.08
PSA 78.476
NB_HD 1
NB_HA 7
fsp3 0.52
Lipinski(0=no;1=yes) 1
NB_atoms 31
XLogP 3.08
PSA 78.476
NB_HD 1
NB_HA 7
fsp3 0.52
Lipinski(0=no;1=yes) 1
FDA
NDA 021999 (label) INN (PALIPERIDONE) INVEGA (JANSSEN PHARMS) APPROVAL= AP YEAR= 2006
NDA 022043 (label) INN (PALIPERIDONE) INVEGA (JANSSEN LP) APPROVAL= AP YEAR= 2007 NEWAPPLICATION
NDA 202645 (pdf not found) INN (PALIPERIDONE) PALIPERIDONE (ACTAVIS LABS FL INC) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 203802 (pdf not found) INN (PALIPERIDONE) PALIPERIDONE (RK PHARMA) APPROVAL= AP YEAR= 2015
NDA 205618 (pdf not found) INN (PALIPERIDONE) PALIPERIDONE (SUN PHARM) APPROVAL= AP YEAR= 2018
NDA 204452 (pdf not found) INN (PALIPERIDONE) PALIPERIDONE (INVENTIA) APPROVAL= AP YEAR= 2019
NDA 204707 (pdf not found) INN (PALIPERIDONE) PALIPERIDONE (AMNEAL PHARMS) APPROVAL= AP YEAR= 2019
NDA 212807 (pdf not found) INN (PALIPERIDONE) PALIPERIDONE (CSPC OUYI) APPROVAL= AP YEAR= 2020
NDA 208643 (pdf not found) INN (PALIPERIDONE) PALIPERIDONE (LUPIN LTD) APPROVAL= AP YEAR= 2022
NDA 216174 (pdf not found) INN (PALIPERIDONE) PALIPERIDONE (ASCENT PHARMS INC) APPROVAL= AP YEAR= 2023
NDA 217445 (pdf not found) INN (PALIPERIDONE) PALIPERIDONE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2024
NDA 218330 (pdf not found) INN (PALIPERIDONE) PALIPERIDONE (ALEMBIC) APPROVAL= AP YEAR= 2024
NDA 218514 (pdf not found) INN (PALIPERIDONE) PALIPERIDONE (AJANTA PHARMA LTD) APPROVAL= AP YEAR= 2024
NDA 205559 (pdf not found) INN (PALIPERIDONE) PALIPERIDONE (DR REDDYS) APPROVAL= AP YEAR= 2025
NDA 021999 (label) INN (PALIPERIDONE) INVEGA (JANSSEN PHARMS) APPROVAL= AP YEAR= 2006
NDA 022043 (label) INN (PALIPERIDONE) INVEGA (JANSSEN LP) APPROVAL= AP YEAR= 2007 NEWAPPLICATION
NDA 202645 (pdf not found) INN (PALIPERIDONE) PALIPERIDONE (ACTAVIS LABS FL INC) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 203802 (pdf not found) INN (PALIPERIDONE) PALIPERIDONE (RK PHARMA) APPROVAL= AP YEAR= 2015
NDA 205618 (pdf not found) INN (PALIPERIDONE) PALIPERIDONE (SUN PHARM) APPROVAL= AP YEAR= 2018
NDA 204452 (pdf not found) INN (PALIPERIDONE) PALIPERIDONE (INVENTIA) APPROVAL= AP YEAR= 2019
NDA 204707 (pdf not found) INN (PALIPERIDONE) PALIPERIDONE (AMNEAL PHARMS) APPROVAL= AP YEAR= 2019
NDA 212807 (pdf not found) INN (PALIPERIDONE) PALIPERIDONE (CSPC OUYI) APPROVAL= AP YEAR= 2020
NDA 208643 (pdf not found) INN (PALIPERIDONE) PALIPERIDONE (LUPIN LTD) APPROVAL= AP YEAR= 2022
NDA 216174 (pdf not found) INN (PALIPERIDONE) PALIPERIDONE (ASCENT PHARMS INC) APPROVAL= AP YEAR= 2023
NDA 217445 (pdf not found) INN (PALIPERIDONE) PALIPERIDONE (ZYDUS PHARMS) APPROVAL= AP YEAR= 2024
NDA 218330 (pdf not found) INN (PALIPERIDONE) PALIPERIDONE (ALEMBIC) APPROVAL= AP YEAR= 2024
NDA 218514 (pdf not found) INN (PALIPERIDONE) PALIPERIDONE (AJANTA PHARMA LTD) APPROVAL= AP YEAR= 2024
NDA 205559 (pdf not found) INN (PALIPERIDONE) PALIPERIDONE (DR REDDYS) APPROVAL= AP YEAR= 2025