e-Drug3D

1197

cas 90357-06-5

CLASS

ANTINEOPLASTIC
ANDROGEN RECEPTOR ANTAGONISTS
R ENANTIOMER IS ACTIVE
TREATMENT OF METASTATIC CARCINOMA OF THE PROSTATE
REMOVE SOURCE OF ANDROGENS

ROUTE (list)

ORAL

PK parameters

Cl 0.32 LITER / HOUR
PPB 96 PERCENT
t1/2 139 HOUR

TARGET ANDROGEN RECEPTOR

PDB
4OKT (CRYSTAL STRUCTURE OF W741L-AR-LBD BOUND WITH CO-REGULATOR PEPTIDE)

Ligand code = 198 (link to the list of PDB complexes)

Download experimental 3D coordinates of 198 with added hydrogens

MW 430.38
NB_atoms 29
XLogP 2.88
PSA 95.733
NB_HD 2
NB_HA 6
fsp3 0.22
Lipinski(0=no;1=yes) 1

FDA
NDA 020498 (label) INN (BICALUTAMIDE) CASODEX (ANI PHARMS) APPROVAL= AP YEAR= 1995
NDA 022310 (label) INN (BICALUTAMIDE) CASODEX (ASTRAZENECA) APPROVAL= AP YEAR= 2008 NEWAPPLICATION
NDA 078575 (label) INN (BICALUTAMIDE) BICALUTAMIDE (SANDOZ) APPROVAL= AP YEAR= 2009
NDA 076932 (label) INN (BICALUTAMIDE) BICALUTAMIDE (TEVA) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 077973 (label) INN (BICALUTAMIDE) BICALUTAMIDE (SYNTHON PHARMS) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 077995 (label) INN (BICALUTAMIDE) BICALUTAMIDE (KUDCO IRELAND) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 078634 (pdf not found) INN (BICALUTAMIDE) BICALUTAMIDE (WATSON LABS TEVA) APPROVAL= AP YEAR= 2009
NDA 078917 (label) INN (BICALUTAMIDE) BICALUTAMIDE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2009
NDA 079089 (label) INN (BICALUTAMIDE) BICALUTAMIDE (ADAPTIS) APPROVAL= AP YEAR= 2009
NDA 079110 (label) INN (BICALUTAMIDE) BICALUTAMIDE (SUN PHARM) APPROVAL= AP YEAR= 2009
NDA 079185 (label) INN (BICALUTAMIDE) BICALUTAMIDE (RISING) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 079045 (pdf not found) INN (BICALUTAMIDE) BICALUTAMIDE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 078285 (pdf not found) INN (BICALUTAMIDE) BICALUTAMIDE (ROXANE) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 091011 (pdf not found) INN (BICALUTAMIDE) BICALUTAMIDE (CHARTWELL RX) APPROVAL= AP YEAR= 2015
NDA 200274 (pdf not found) INN (BICALUTAMIDE) BICALUTAMIDE (APOTEX) APPROVAL= AP YEAR= 2015 DISCONTINUED