e-Drug3D

1184

cas 13392-28-4

CLASS

ANTIINFECTIVES
ANTIVIRAL
ANTI INFLUENZA A
RESISTANCE OBSERVED
CHANNEL BLOCKER

ROUTE (list)

ORAL

PK parameters

Cl 3.9 LITER / HOUR
PPB 40 PERCENT
t1/2 39 HOUR

TARGET PROTON TRANSPORTER M2 (PMID23480101)

PDB
2BOC (INFLUENZA A M2 TRANSMEMBRANE DOMAIN BOUND TO RIMANTADINE IN THE INWARD(OPEN) CONFORMATION)

Ligand code = EU7 (link to the list of PDB complexes)

Download experimental 3D coordinates of EU7 with added hydrogens

MW 179.30
NB_atoms 13
XLogP 2.55
PSA 22.607
NB_HD 2
NB_HA 1
fsp3 1.00
Lipinski(0=no;1=yes) 1

FDA
NDA 019649 (label) INN (RIMANTADINE HYDROCHLORIDE) FLUMADINE (SUN PHARM INDS INC) APPROVAL= AP YEAR= 1993 NEWMOLECULARENTITY DISCONTINUED
NDA 019650 (label) INN (RIMANTADINE HYDROCHLORIDE) FLUMADINE (FOREST LABS) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 075916 (pdf not found) INN (RIMANTADINE HYDROCHLORIDE) RIMANTADINE HYDROCHLORIDE (IMPAX LABS INC) APPROVAL= AP YEAR= 2001 DISCONTINUED
NDA 076132 (pdf not found) INN (RIMANTADINE HYDROCHLORIDE) RIMANTADINE HYDROCHLORIDE (IMPAX LABS) APPROVAL= AP YEAR= 2002
NDA 076375 (pdf not found) INN (RIMANTADINE HYDROCHLORIDE) RIMANTADINE HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 2003 DISCONTINUED