e-Drug3D

1176

cas 63590-64-7

CLASS

GENITO
BENIGN PROSTATIC HYPERPLASIA
ANTIHYPERTENSIVE
ALPHA-1-SELECTIVE ADRENOCEPTOR BLOCKING AGENT

ROUTE (list)

ORAL

PK parameters

Tmax 1 HOUR
VD 58 LITER
Cl 4 LITER / HOUR
PPB 99 PERCENT
t1/2 12 HOUR

TARGET ALPHA-1 ADRENERGIC RECEPTOR

PDB
4O33 (CRYSTAL STRUCTURE OF HUMAN PGK1 3PG AND TERAZOSIN(TZN) TERNARY COMPLEX)

Ligand code = TZN (link to the list of PDB complexes)

Download experimental 3D coordinates of TZN with added hydrogens

MW 387.44
NB_atoms 28
XLogP 1.06
PSA 98.159
NB_HD 2
NB_HA 9
fsp3 0.53
Lipinski(0=no;1=yes) 1

FDA
NDA 019057 (pdf not found) INN (TERAZOSIN HYDROCHLORIDE) HYTRIN (ABBOTT) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 020347 (pdf not found) INN (TERAZOSIN HYDROCHLORIDE) HYTRIN (ABBOTT) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 074651 (pdf not found) INN (TERAZOSIN HYDROCHLORIDE) TERAZOSIN HYDROCHLORIDE (LEMMON CO) APPROVAL= TA YEAR= 1997 OBSOLETE
NDA 074315 (pdf not found) INN (TERAZOSIN HYDROCHLORIDE) TERAZOSIN HYDROCHLORIDE (SANDOZ) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 074823 (pdf not found) INN (TERAZOSIN HYDROCHLORIDE) TERAZOSIN HYDROCHLORIDE (APNAR PHARMA LP) APPROVAL= AP YEAR= 1998
NDA 074446 (pdf not found) INN (TERAZOSIN HYDROCHLORIDE) TERAZOSIN HYDROCHLORIDE (TEVA) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 074530 (pdf not found) INN (TERAZOSIN HYDROCHLORIDE) TERAZOSIN HYDROCHLORIDE (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 074657 (pdf not found) INN (TERAZOSIN HYDROCHLORIDE) TERAZOSIN HYDROCHLORIDE (CHARTWELL RX) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 075140 (pdf not found) INN (TERAZOSIN HYDROCHLORIDE) TERAZOSIN HYDROCHLORIDE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 075384 (pdf not found) INN (TERAZOSIN HYDROCHLORIDE) TERAZOSIN HYDROCHLORIDE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 075667 (pdf not found) INN (TERAZOSIN HYDROCHLORIDE) TERAZOSIN HYDROCHLORIDE (BIONPHARMA) APPROVAL= AP YEAR= 2000
NDA 075498 (pdf not found) INN (TERAZOSIN HYDROCHLORIDE) TERAZOSIN HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 2001 DISCONTINUED
NDA 075614 (pdf not found) INN (TERAZOSIN HYDROCHLORIDE) TERAZOSIN HYDROCHLORIDE (HERITAGE PHARMA AVET) APPROVAL= AP YEAR= 2001
NDA 076021 (pdf not found) INN (TERAZOSIN HYDROCHLORIDE) TERAZOSIN HYDROCHLORIDE (RANBAXY LABS LTD) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 075317 (pdf not found) INN (TERAZOSIN HYDROCHLORIDE) TERAZOSIN HYDROCHLORIDE (JUBILANT CADISTA) APPROVAL= AP YEAR= 2004
NDA 218139 (pdf not found) INN (TERAZOSIN HYDROCHLORIDE) TEZRULY (NOVITIUM PHARMA) APPROVAL= AP YEAR= 2024
NDA 219482 (pdf not found) INN (TERAZOSIN HYDROCHLORIDE) TERAZOSIN HYDROCHLORIDE (AJANTA PHARMA LTD) APPROVAL= AP YEAR= 2025