e-Drug3D
1170
NIMODIPINE
INN
NIMODIPINE
cas 66085-59-4
CLASS
CARDIOVASCULAR
VASODILATOR
CALCIUM CHANNEL ANTAGONIST
ANTIHYPERTENSIVE AGENTS
ROUTE (list)
ORAL
ATC code
C08CA06
PK parameters
F 13 PERCENT
Tmax 1 HOUR
VD 66 LITER
Cl 54 LITER / HOUR
PPB 95 PERCENT
t1/2 1.5 HOUR
Solubility
PRACTICALLY INSOLUBLE IN WATER
TARGET CALCIUM CHANNEL
Voltage-dependent L-type calcium channel subunit alpha-1C UNIPROT Q13936 CACNA1C
Voltage-dependent L-type calcium channel subunit alpha-1D UNIPROT Q01668 CACNA1D
Formula:
C21H26N2O7
Calculated chemical properties:
MW 418.44
NB_atoms 30
XLogP 0
PSA 106.51
NB_HD 1
NB_HA 8
fsp3 0.43
Lipinski(0=no;1=yes) 1
NB_atoms 30
XLogP 0
PSA 106.51
NB_HD 1
NB_HA 8
fsp3 0.43
Lipinski(0=no;1=yes) 1
FDA
NDA 018869 (label) INN (NIMODIPINE) NIMOTOP (BAYER PHARMS) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 077067 (pdf not found) INN (NIMODIPINE) NIMODIPINE (SUN PHARM INDS INC) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 077811 (pdf not found) INN (NIMODIPINE) NIMODIPINE (HERITAGE) APPROVAL= AP YEAR= 2007
NDA 076740 (pdf not found) INN (NIMODIPINE) NIMODIPINE (BIONPHARMA) APPROVAL= AP YEAR= 2008
NDA 203340 (label) INN (NIMODIPINE) NYMALIZE (AZURITY) APPROVAL= AP YEAR= 2013
NDA 090103 (pdf not found) INN (NIMODIPINE) NIMODIPINE (THEPHARMANETWORK LLC) APPROVAL= AP YEAR= 2014
NDA 201832 (pdf not found) INN (NIMODIPINE) NIMODIPINE (SOFGEN PHARMS) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 216937 (pdf not found) INN (NIMODIPINE) NIMODIPINE (ANNORA PHARMA) APPROVAL= AP YEAR= 2024
NDA 213409 (pdf not found) INN (NIMODIPINE) NIMODIPINE (ALKEM LABS LTD) APPROVAL= AP YEAR= 2025
NDA 018869 (label) INN (NIMODIPINE) NIMOTOP (BAYER PHARMS) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 077067 (pdf not found) INN (NIMODIPINE) NIMODIPINE (SUN PHARM INDS INC) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 077811 (pdf not found) INN (NIMODIPINE) NIMODIPINE (HERITAGE) APPROVAL= AP YEAR= 2007
NDA 076740 (pdf not found) INN (NIMODIPINE) NIMODIPINE (BIONPHARMA) APPROVAL= AP YEAR= 2008
NDA 203340 (label) INN (NIMODIPINE) NYMALIZE (AZURITY) APPROVAL= AP YEAR= 2013
NDA 090103 (pdf not found) INN (NIMODIPINE) NIMODIPINE (THEPHARMANETWORK LLC) APPROVAL= AP YEAR= 2014
NDA 201832 (pdf not found) INN (NIMODIPINE) NIMODIPINE (SOFGEN PHARMS) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 216937 (pdf not found) INN (NIMODIPINE) NIMODIPINE (ANNORA PHARMA) APPROVAL= AP YEAR= 2024
NDA 213409 (pdf not found) INN (NIMODIPINE) NIMODIPINE (ALKEM LABS LTD) APPROVAL= AP YEAR= 2025