e-Drug3D

117

cas 54-85-3

CLASS

ANTIINFECTIVES
TUBERCULOSTATIC
ANTIFUNGAL
ANTIBIOTIC
ANTIBACTERIAL
ANTITUBERCULAR
FATTY ACID SYNTHESIS INHIBITORS

ROUTE (list)

ORAL INJECTION

PK parameters

F 100 PERCENT
Tmax 1.5 HOUR
VD 53.3 LITER (65 KILOGRAM)
Cl 24.02 LITER / HOUR
PPB 0 PERCENT
t1/2 2.8 HOUR

TARGET CATALASE PEROXIDASE (KATG)

PDB
4PAE (CRYSTAL STRUCTURE OF CATALASE-PEROXIDASE (KATG) W78F MUTANT FROM SYNECHOCOCCUS ELONGATUS PCC7942)

Ligand code = NIZ (link to the list of PDB complexes)

Download experimental 3D coordinates of NIZ with added hydrogens

MW 137.15
NB_atoms 10
XLogP -0.31
PSA 65.566
NB_HD 3
NB_HA 4
fsp3 0.00
Lipinski(0=no;1=yes) 1

FDA
NDA 008392 (pdf not found) INN (ISONIAZID) NYDRAZID (BRISTOL MYERS SQUIBB) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 008420 (pdf not found) INN (ISONIAZID) RIMIFON (ROCHE) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 008499 (pdf not found) INN (ISONIAZID) ISONIAZID (LILLY) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 080134 (pdf not found) INN (ISONIAZID) HYZYD (MEDPOINTE PHARM HLC) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 080270 (pdf not found) INN (ISONIAZID) ISONIAZID (IVAX SUB TEVA PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 080401 (pdf not found) INN (ISONIAZID) ISONIAZID (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 080935 (pdf not found) INN (ISONIAZID) INH (NOVARTIS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 083060 (pdf not found) INN (ISONIAZID) ISONIAZID (PERRIGO) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 083178 (pdf not found) INN (ISONIAZID) ISONIAZID (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 083632 (pdf not found) INN (ISONIAZID) ISONIAZID (HALSEY) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089816 (pdf not found) INN (ISONIAZID) ISONIAZID (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 008662 (label) INN (ISONIAZID) NYDRAZID (SANDOZ) APPROVAL= AP YEAR= 1952 DISCONTINUED
NDA 008678 (label) INN (ISONIAZID) ISONIAZID (EPIC PHARMA LLC) APPROVAL= AP YEAR= 1952 DISCONTINUED
NDA 080136 (pdf not found) INN (ISONIAZID) ISONIAZID (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1970 DISCONTINUED
NDA 080120 (pdf not found) INN (ISONIAZID) ISONIAZID (WHITEWORTH TOWN PLSN) APPROVAL= AP YEAR= 1971 DISCONTINUED
NDA 080330 (pdf not found) INN (ISONIAZID) DOW-ISONIAZID (DOW PHARM) APPROVAL= AP YEAR= 1971 DISCONTINUED
NDA 080126 (pdf not found) INN (ISONIAZID) STANOZIDE (EVERYLIFE) APPROVAL= AP YEAR= 1972 DISCONTINUED
NDA 080212 (pdf not found) INN (ISONIAZID) ISONIAZID (HIKMA INTL PHARMS) APPROVAL= AP YEAR= 1972 DISCONTINUED
NDA 080521 (pdf not found) INN (ISONIAZID) ISONIAZID (WATSON LABS) APPROVAL= AP YEAR= 1972 DISCONTINUED
NDA 080522 (pdf not found) INN (ISONIAZID) ISONIAZID (WATSON LABS) APPROVAL= AP YEAR= 1972 DISCONTINUED
NDA 080523 (pdf not found) INN (ISONIAZID) ISONIAZID (WATSON LABS) APPROVAL= AP YEAR= 1972 DISCONTINUED
NDA 080936 (pdf not found) INN (ISONIAZID) ISONIAZID (GENUS) APPROVAL= AP YEAR= 1972 DISCONTINUED
NDA 080937 (pdf not found) INN (ISONIAZID) ISONIAZID (GENUS) APPROVAL= AP YEAR= 1972 DISCONTINUED
NDA 080941 (pdf not found) INN (ISONIAZID) ISONIAZID (MK LABS) APPROVAL= AP YEAR= 1972 DISCONTINUED
NDA 008428 (pdf not found) INN (ISONIAZID) ISONIAZID (PANRAY) APPROVAL= AP YEAR= 1973 DISCONTINUED
NDA 080153 (pdf not found) INN (ISONIAZID) ISONIAZID (IMPAX LABS) APPROVAL= AP YEAR= 1973 DISCONTINUED
NDA 083610 (pdf not found) INN (ISONIAZID) ISONIAZID (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 1974 DISCONTINUED
NDA 084050 (pdf not found) INN (ISONIAZID) ISONIAZID (NEXGEN PHARMA INC) APPROVAL= AP YEAR= 1974 DISCONTINUED
NDA 061884 (pdf not found) INN (ISONIAZID ; RIFAMPIN) RIFAMATE (SANOFI AVENTIS US) APPROVAL= AP YEAR= 1975 DISCONTINUED
NDA 080140 (pdf not found) INN (ISONIAZID) LANIAZID (CHARTWELL MOLECULAR) APPROVAL= AP YEAR= 1975 DISCONTINUED
NDA 080368 (pdf not found) INN (ISONIAZID) ISONIAZID (PHOENIX LABS NY) APPROVAL= AP YEAR= 1975 DISCONTINUED
NDA 083633 (pdf not found) INN (ISONIAZID) ISONIAZID (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 085091 (pdf not found) INN (ISONIAZID) ISONIAZID (PHARMAVITE) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 085784 (pdf not found) INN (ISONIAZID) ISONIAZID (WATSON LABS) APPROVAL= AP YEAR= 1977 DISCONTINUED
NDA 085790 (pdf not found) INN (ISONIAZID) ISONIAZID (WATSON LABS) APPROVAL= AP YEAR= 1977 DISCONTINUED
NDA 087425 (pdf not found) INN (ISONIAZID) ISONIAZID (HIKMA INTL PHARMS) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 080132 (pdf not found) INN (ISONIAZID) ISONIAZID (PUREPAC PHARM) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 088119 (pdf not found) INN (ISONIAZID) ISONIAZID (DURAMED PHARMS BARR) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 088231 (pdf not found) INN (ISONIAZID) ISONIAZID (DURAMED PHARMS BARR) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 088235 (pdf not found) INN (ISONIAZID) ISONIAZID (CMP PHARMA INC) APPROVAL= AP YEAR= 1983
NDA 089243 (pdf not found) INN (ISONIAZID) LANIAZID (LANNETT) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 089776 (pdf not found) INN (ISONIAZID) LANIAZID (CHARTWELL MOLECULAR) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 050705 (label) INN (ISONIAZID ; PYRAZINAMIDE ; RIFAMPIN) RIFATER (SANOFI AVENTIS US) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 040090 (pdf not found) INN (ISONIAZID) ISONIAZID (OMNIVIUM PHARMS) APPROVAL= AP YEAR= 1997
NDA 081118 (pdf not found) INN (ISONIAZID) ISONIAZID (CHARTWELL RX) APPROVAL= AP YEAR= 1997
NDA 040648 (pdf not found) INN (ISONIAZID) ISONIAZID (SANDOZ) APPROVAL= AP YEAR= 2005
NDA 065221 (pdf not found) INN (ISONIAZID ; RIFAMPIN) RIFAMPIN AND ISONIAZID (HIKMA INTL PHARMS) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 202610 (pdf not found) INN (ISONIAZID) ISONIAZID (THEPHARMANETWORK LLC) APPROVAL= AP YEAR= 2014