e-Drug3D

1169

cas 54143-55-4

CLASS

CARDIOVASCULAR
ANTIARRHYTHMIC
CARDIAC DEPRESSANT

ROUTE (list)

ORAL

PK parameters

VD 366 LITER
Cl 17.6 LITER / HOUR
PPB 48 PERCENT
t1/2 12 HOUR

TARGET SODIUM CHANNEL NAV1.5

PDB
6MVX (NAVAB VOLTAGE-GATED SODIUM CHANNEL, I217C, IN COMPLEX WITH CLASS 1C ANTI-ARRHYTHMIC FLECAINIDE)

Ligand code = K4D (link to the list of PDB complexes)

Download experimental 3D coordinates of K4D with added hydrogens

MW 414.35
NB_atoms 28
XLogP 3.44
PSA 59.016
NB_HD 2
NB_HA 5
fsp3 0.59
Lipinski(0=no;1=yes) 1

FDA
NDA 018830 (pdf not found) INN (FLECAINIDE ACETATE) TAMBOCOR (ALVOGEN) APPROVAL= AP YEAR= 1985 NEWMOLECULARENTITY DISCONTINUED
NDA 075442 (pdf not found) INN (FLECAINIDE ACETATE) FLECAINIDE ACETATE (AMNEAL PHARM) APPROVAL= AP YEAR= 2001
NDA 075882 (pdf not found) INN (FLECAINIDE ACETATE) FLECAINIDE ACETATE (ANI PHARMS) APPROVAL= AP YEAR= 2002
NDA 076030 (pdf not found) INN (FLECAINIDE ACETATE) FLECAINIDE ACETATE (ANI PHARMS) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 076278 (pdf not found) INN (FLECAINIDE ACETATE) FLECAINIDE ACETATE (HIKMA) APPROVAL= AP YEAR= 2003
NDA 076421 (pdf not found) INN (FLECAINIDE ACETATE) FLECAINIDE ACETATE (SUN PHARM INDS LTD) APPROVAL= AP YEAR= 2003
NDA 079164 (pdf not found) INN (FLECAINIDE ACETATE) FLECAINIDE ACETATE (CHARTWELL) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 202821 (pdf not found) INN (FLECAINIDE ACETATE) FLECAINIDE ACETATE (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2017
NDA 210683 (pdf not found) INN (FLECAINIDE ACETATE) FLECAINIDE ACETATE (BEXIMCO PHARMS USA) APPROVAL= AP YEAR= 2020
NDA 215599 (pdf not found) INN (FLECAINIDE ACETATE) FLECAINIDE ACETATE (YICHANG HUMANWELL) APPROVAL= AP YEAR= 2022