e-Drug3D

1168

cas 5104-49-4

CLASS

MUSCULO-SKELETAL SYSTEM
ANALGESICS
NSAID
ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL
CYCLOOXYGENASE INHIBITORS

ROUTE (list)

ORAL OPHTHALMIC

PK parameters

F 96 PERCENT
Tmax 2 HOUR
VD 7.8 LITER (65 KILOGRAM)
Cl 1.08 LITER / HOUR (EQN)
PPB 99 PERCENT
t1/2 5 HOUR

TARGET PROSTAGLANDIN G/H SYNTHASE 1
PROSTAGLANDIN G/H SYNTHASE 2

PDB
3RR3 (STRUCTURE OF (R)-FLURBIPROFEN BOUND TO MCOX-2)

Ligand code = FLR (link to the list of PDB complexes)

Download experimental 3D coordinates of FLR with added hydrogens

MW 243.25
NB_atoms 18
XLogP 2.35
PSA 34.327
NB_HD 0
NB_HA 2
fsp3 0.13
Lipinski(0=no;1=yes) 1

FDA
NDA 019404 (label) INN (FLURBIPROFEN SODIUM) OCUFEN (ALLERGAN) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 018766 (label) INN (FLURBIPROFEN) ANSAID (PHARMACIA AND UPJOHN) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 074358 (pdf not found) INN (FLURBIPROFEN) FLURBIPROFEN (NATCO PHARMA) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 074405 (pdf not found) INN (FLURBIPROFEN) FLURBIPROFEN (TEVA) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 074411 (pdf not found) INN (FLURBIPROFEN) FLURBIPROFEN (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 074431 (pdf not found) INN (FLURBIPROFEN) FLURBIPROFEN (NEW HEIGHTSRX) APPROVAL= AP YEAR= 1995
NDA 074447 (pdf not found) INN (FLURBIPROFEN SODIUM) FLURBIPROFEN SODIUM (BAUSCH AND LOMB) APPROVAL= AP YEAR= 1995
NDA 074448 (pdf not found) INN (FLURBIPROFEN) FLURBIPROFEN (RISING) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 074560 (pdf not found) INN (FLURBIPROFEN) FLURBIPROFEN (THERAGEN) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 074647 (pdf not found) INN (FLURBIPROFEN) FLURBIPROFEN (PLIVA) APPROVAL= AP YEAR= 1997 DISCONTINUED
NDA 075058 (pdf not found) INN (FLURBIPROFEN) FLURBIPROFEN (SUN PHARM INDS INC) APPROVAL= AP YEAR= 2001 DISCONTINUED