e-Drug3D

1156

cas 1134-47-0

CLASS

MUSCULO-SKELETAL SYSTEM
MUSCLE RELAXANT
GABA AGONISTS

ROUTE (list)

ORAL INTRATHECAL

PK parameters

VD 59 LITER
Cl 10 LITER / HOUR
PPB 30 PERCENT
t1/2 5 HOUR

TARGET GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR

PDB
4MS4 (CRYSTAL STRUCTURE OF THE EXTRACELLULAR DOMAIN OF HUMAN GABA(B) RECEPTOR BOUND TO THE AGONIST BACLOFEN)

Ligand code = 2C0 (link to the list of PDB complexes)

Download experimental 3D coordinates of 2C0 with added hydrogens

MW 212.65
NB_atoms 14
XLogP 0.52
PSA 58.602
NB_HD 2
NB_HA 3
fsp3 0.30
Lipinski(0=no;1=yes) 1

FDA
NDA 071260 (pdf not found) INN (BACLOFEN) BACLOFEN (USL PHARMA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071261 (pdf not found) INN (BACLOFEN) BACLOFEN (USL PHARMA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 017851 (pdf not found) INN (BACLOFEN) LIORESAL (NOVARTIS) APPROVAL= AP YEAR= 1977 DISCONTINUED
NDA 072234 (pdf not found) INN (BACLOFEN) BACLOFEN (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 1988
NDA 072235 (pdf not found) INN (BACLOFEN) BACLOFEN (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 1988
NDA 072824 (pdf not found) INN (BACLOFEN) BACLOFEN (WATSON LABS) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 072825 (pdf not found) INN (BACLOFEN) BACLOFEN (WATSON LABS) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 020075 (pdf not found) INN (BACLOFEN) LIORESAL (AMNEAL) APPROVAL= AP YEAR= 1992
NDA 073043 (pdf not found) INN (BACLOFEN) BACLOFEN (TEVA) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 073044 (pdf not found) INN (BACLOFEN) BACLOFEN (TEVA) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 073092 (pdf not found) INN (BACLOFEN) BACLOFEN (WATSON LABS) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 073093 (pdf not found) INN (BACLOFEN) BACLOFEN (WATSON LABS) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 074584 (pdf not found) INN (BACLOFEN) BACLOFEN (YILING) APPROVAL= AP YEAR= 1996
NDA 074698 (pdf not found) INN (BACLOFEN) BACLOFEN (WATSON LABS) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 021589 (pdf not found) INN (BACLOFEN) KEMSTRO (UCB INC) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 077068 (pdf not found) INN (BACLOFEN) BACLOFEN (PH HEALTH) APPROVAL= AP YEAR= 2005
NDA 077121 (pdf not found) INN (BACLOFEN) BACLOFEN (PHARMOBEDIENT) APPROVAL= AP YEAR= 2005
NDA 077156 (pdf not found) INN (BACLOFEN) BACLOFEN (VINTAGE PHARMS) APPROVAL= AP YEAR= 2005 OBSOLETE
NDA 077181 (pdf not found) INN (BACLOFEN) BACLOFEN (PHARMOBEDIENT) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 077241 (pdf not found) INN (BACLOFEN) BACLOFEN (LANNETT CO INC) APPROVAL= AP YEAR= 2005
NDA 077862 (pdf not found) INN (BACLOFEN) BACLOFEN (SUN PHARM INDS INC) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 077984 (pdf not found) INN (BACLOFEN) BACLOFEN (CARACO) APPROVAL= AP YEAR= 2006 OBSOLETE
NDA 077088 (pdf not found) INN (BACLOFEN) BACLOFEN (OXFORD PHARMS) APPROVAL= AP YEAR= 2007
NDA 077089 (pdf not found) INN (BACLOFEN) BACLOFEN () APPROVAL= AP YEAR= 2007
NDA 077971 (pdf not found) INN (BACLOFEN) BACLOFEN (IMPAX) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 078146 (pdf not found) INN (BACLOFEN) BACLOFEN (IMPAX LABS) APPROVAL= AP YEAR= 2007 OBSOLETE
NDA 078220 (pdf not found) INN (BACLOFEN) BACLOFEN (LANNETT) APPROVAL= AP YEAR= 2007 OBSOLETE
NDA 078401 (pdf not found) INN (BACLOFEN) BACLOFEN (NORTHSTAR HLTHCARE) APPROVAL= AP YEAR= 2009
NDA 078504 (pdf not found) INN (BACLOFEN) BACLOFEN (NORTHSTAR HLTHCARE) APPROVAL= AP YEAR= 2009
NDA 090334 (pdf not found) INN (BACLOFEN) BACLOFEN (APPCO) APPROVAL= AP YEAR= 2010
NDA 022462 (pdf not found) INN (BACLOFEN) GABLOFEN (PIRAMAL CRITICAL) APPROVAL= AP YEAR= 2010
NDA 091193 (pdf not found) INN (BACLOFEN) BACLOFEN (AMNEAL) APPROVAL= AP YEAR= 2016
NDA 209102 (pdf not found) INN (BACLOFEN) BACLOFEN (RUBICON RESEARCH) APPROVAL= AP YEAR= 2017
NDA 209592 (pdf not found) INN (BACLOFEN) BACLOFEN (PHARMOBEDIENT) APPROVAL= AP YEAR= 2018
NDA 209594 (pdf not found) INN (BACLOFEN) BACLOFEN (PHARMOBEDIENT) APPROVAL= AP YEAR= 2018
NDA 211659 (pdf not found) INN (BACLOFEN) BACLOFEN (ZYDUS LIFESCIENCES) APPROVAL= AP YEAR= 2018
NDA 211555 (pdf not found) INN (BACLOFEN) BACLOFEN (HIBROW HLTHCARE) APPROVAL= AP YEAR= 2019
NDA 208193 (pdf not found) INN (BACLOFEN) OZOBAX (METACEL PHARMS LLC) APPROVAL= AP YEAR= 2019
NDA 210048 (pdf not found) INN (BACLOFEN) BACLOFEN (MAIA PHARMS INC) APPROVAL= AP YEAR= 2019
NDA 210315 (pdf not found) INN (BACLOFEN) BACLOFEN (MAIA PHARMS INC) APPROVAL= AP YEAR= 2019
NDA 212067 (pdf not found) INN (BACLOFEN) BACLOFEN (UNICHEM) APPROVAL= AP YEAR= 2020
NDA 212378 (pdf not found) INN (BACLOFEN) BACLOFEN (ANDAS 5 HOLDING) APPROVAL= AP YEAR= 2020
NDA 210777 (pdf not found) INN (BACLOFEN) BACLOFEN (MAIA PHARMS INC) APPROVAL= AP YEAR= 2021
NDA 214374 (pdf not found) INN (BACLOFEN) BACLOFEN (RISING) APPROVAL= AP YEAR= 2021
NDA 214099 (pdf not found) INN (BACLOFEN) BACLOFEN (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2021
NDA 214114 (pdf not found) INN (BACLOFEN) BACLOFEN (BEXIMCO PHARMS USA) APPROVAL= AP YEAR= 2021
NDA 215422 (pdf not found) INN (BACLOFEN) LYVISPAH (AMNEAL) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 215602 (pdf not found) INN (BACLOFEN) FLEQSUVY (AZURITY) APPROVAL= AP YEAR= 2022
NDA 215885 (pdf not found) INN (BACLOFEN) BACLOFEN (MANKIND PHARMA) APPROVAL= AP YEAR= 2022
NDA 217252 (pdf not found) INN (BACLOFEN) BACLOFEN (ANI PHARMS) APPROVAL= AP YEAR= 2023
NDA 217324 (pdf not found) INN (BACLOFEN) BACLOFEN (RUBICON RESEARCH) APPROVAL= AP YEAR= 2023
NDA 216309 (pdf not found) INN (BACLOFEN) BACLOFEN (HERITAGE) APPROVAL= AP YEAR= 2023 DISCONTINUED
NDA 217687 (pdf not found) INN (BACLOFEN) BACLOFEN (MICRO LABS) APPROVAL= AP YEAR= 2023
NDA 214445 (pdf not found) INN (BACLOFEN) BACLOFEN (RUBICON RESEARCH) APPROVAL= AP YEAR= 2024
NDA 217788 (pdf not found) INN (BACLOFEN) BACLOFEN (GRAVITI PHARMS) APPROVAL= AP YEAR= 2024