e-Drug3D

1155

cas 34368-04-2

CLASS

CARDIOVASCULAR
CARDIOTONIC
ADRENERGIC BETA AGONISTS
SYMPATHOMIMETIC
CATECHOLAMINE

ROUTE (list)

INJECTION

PK parameters

VD 13 LITER
Cl 249 LITER / HOUR
t1/2 0.033 HOUR

TARGET BETA-1 ADRENERGIC RECEPTOR
CATECHOL O-METHYLTRANSFERASE (COMT)

PDB
2Y00 (TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND PARTIAL AGONIST DOBUTAMINE (CRYSTAL DOB92))

Ligand code = Y00 (link to the list of PDB complexes)

Download experimental 3D coordinates of Y00 with added hydrogens

MW 301.37
NB_atoms 22
XLogP 2.96
PSA 75.809
NB_HD 4
NB_HA 4
fsp3 0.33
Lipinski(0=no;1=yes) 1

FDA
NDA 017820 (pdf not found) INN (DOBUTAMINE HYDROCHLORIDE) DOBUTREX (LILLY) APPROVAL= AP YEAR= 1978 DISCONTINUED
NDA 020201 (pdf not found) INN (DOBUTAMINE HYDROCHLORIDE) DOBUTAMINE HYDROCHLORIDE IN DEXTROSE 5% IN PLASTIC CONTAINER (HOSPIRA) APPROVAL= AP YEAR= 1993
NDA 020255 (pdf not found) INN (DOBUTAMINE HYDROCHLORIDE) DOBUTAMINE HYDROCHLORIDE IN DEXTROSE 5% IN PLASTIC CONTAINER (BAXTER HLTHCARE) APPROVAL= AP YEAR= 1993
NDA 020269 (pdf not found) INN (DOBUTAMINE HYDROCHLORIDE) DOBUTAMINE HYDROCHLORIDE IN DEXTROSE 5% (HOSPIRA) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 074086 (pdf not found) INN (DOBUTAMINE HYDROCHLORIDE) DOBUTAMINE HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 1993
NDA 074114 (pdf not found) INN (DOBUTAMINE HYDROCHLORIDE) DOBUTAMINE HYDROCHLORIDE (WATSON LABS) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 074206 (pdf not found) INN (DOBUTAMINE HYDROCHLORIDE) DOBUTAMINE HYDROCHLORIDE (TEVA PARENTERAL) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 074277 (pdf not found) INN (DOBUTAMINE HYDROCHLORIDE) DOBUTAMINE HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 1994
NDA 074098 (pdf not found) INN (DOBUTAMINE HYDROCHLORIDE) DOBUTAMINE HYDROCHLORIDE (TELIGENT) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 074292 (pdf not found) INN (DOBUTAMINE HYDROCHLORIDE) DOBUTAMINE HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 1995 DISCONTINUED
NDA 074381 (pdf not found) INN (DOBUTAMINE HYDROCHLORIDE) DOBUTAMINE HYDROCHLORIDE (BAXTER HLTHCARE) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074634 (pdf not found) INN (DOBUTAMINE HYDROCHLORIDE) DOBUTAMINE HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 074279 (pdf not found) INN (DOBUTAMINE HYDROCHLORIDE) DOBUTAMINE HYDROCHLORIDE (WATSON LABS INC) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 074545 (pdf not found) INN (DOBUTAMINE HYDROCHLORIDE) DOBUTAMINE HYDROCHLORIDE (LUITPOLD) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 074995 (pdf not found) INN (DOBUTAMINE HYDROCHLORIDE) DOBUTAMINE HYDROCHLORIDE (DR REDDYS) APPROVAL= AP YEAR= 1998 DISCONTINUED
NDA 216131 (pdf not found) INN (DOBUTAMINE HYDROCHLORIDE) DOBUTAMINE HYDROCHLORIDE (SLATE RUN PHARMA) APPROVAL= AP YEAR= 2022