e-Drug3D

1153

LUMEFANTRINE

INN
LUMEFANTRINE

cas 82186-77-4

CLASS

ANTIPARASITIC
ANTIMALARIALS
INHIBITS HEMOZOIN FORMATION
MEMBRANE SCRAMBLING LEADING TO PHOSPHATIDYLSERINE-EXPOSURE AT THE ERYTHROCYTE SURFACE

ROUTE (list)

ORAL

ATC code

P01BF01

PK parameters

PPB 99.7 PERCENT
t1/2 101 HOUR

Solubility

INSOLUBLE IN WATER

Target

DrugCentral

Unknown

Download SDF file

2-(dibutylamino)-1-[(9Z)-2,7-dichloro-9-[(4-chlorophenyl)methylidene]fluoren-4-yl]ethanol

Formula:
C30H32Cl3NO

Calculated chemical properties:

MW 528.92
NB_atoms 35
XLogP 9.15
PSA 24.174
NB_HD 1
NB_HA 2
fsp3 0.33
Lipinski(0=no;1=yes) 0

FDA
NDA 022268 (pdf not found) INN (ARTEMETHER ; LUMEFANTRINE) COARTEM (NOVARTIS) APPROVAL= AP YEAR= 2009 NEWMOLECULARENTITY