e-Drug3D

115

cas 50-33-9

CLASS

METABOLISM
TREATMENT OF RHEUMATOID DISEASES
ANALGESIC

ROUTE (list)

ORAL

PK parameters

Tmax 3 HOUR
VD 10 LITER
Cl 1.36 LITER / HOUR (65 KILOGRAM)
PPB 98.5 PERCENT
t1/2 79 HOUR (PMID23721873)

TARGET CARBONYL REDUCTASE

PDB
2BXQ (HUMAN SERUM ALBUMIN COMPLEXED WITH MYRISTATE, PHENYLBUTAZONE AND INDOMETHACIN)

Ligand code = P1Z (link to the list of PDB complexes)

Download experimental 3D coordinates of P1Z with added hydrogens

MW 308.37
NB_atoms 23
XLogP 3.79
PSA 40.137
NB_HD 0
NB_HA 4
fsp3 0.26
Lipinski(0=no;1=yes) 1

FDA
NDA 087091 (pdf not found) INN (PHENYLBUTAZONE) AZOLID (SANOFI AVENTIS US) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 008319 (pdf not found) INN (PHENYLBUTAZONE) BUTAZOLIDIN (NOVARTIS) APPROVAL= AP YEAR= 1977 DISCONTINUED
NDA 086151 (pdf not found) INN (PHENYLBUTAZONE) PHENYLBUTAZONE (WATSON LABS) APPROVAL= AP YEAR= 1979 DISCONTINUED
NDA 084339 (pdf not found) INN (PHENYLBUTAZONE) PHENYLBUTAZONE (FOSUN PHARMA) APPROVAL= AP YEAR= 1980 DISCONTINUED
NDA 087260 (pdf not found) INN (PHENYLBUTAZONE) AZOLID (SANOFI AVENTIS US) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 087674 (pdf not found) INN (PHENYLBUTAZONE) PHENYLBUTAZONE (WATSON LABS) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 087756 (pdf not found) INN (PHENYLBUTAZONE) PHENYLBUTAZONE (WATSON LABS) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 087774 (pdf not found) INN (PHENYLBUTAZONE) PHENYLBUTAZONE (CHARTWELL RX) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 088218 (pdf not found) INN (PHENYLBUTAZONE) PHENYLBUTAZONE (IVAX PHARMS) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 088863 (pdf not found) INN (PHENYLBUTAZONE) PHENYLBUTAZONE (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 088994 (pdf not found) INN (PHENYLBUTAZONE) PHENYLBUTAZONE (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1985 DISCONTINUED