e-Drug3D

1148

MAZINDOL

DISCONTINUED

INN
MAZINDOL

cas 22232-71-9

CLASS

METABOLISM
CNS STIMULANT
ANTIANOREXIC
ADRENERGIC UPTAKE INHIBITORS
DOPAMINE UPTAKE INHIBITORS

ROUTE (list)

ORAL

ATC code

A08AA05

PK parameters

Target

TARGET SODIUM-DEPENDENT NORADRENALINE TRANSPORTER
SODIUM-DEPENDENT DOPAMINE TRANSPORTER

PDB
4MME (CRYSTAL STRUCTURE OF LEUBAT (DELTA6 MUTANT) IN COMPLEX WITH MAZINDOL)

Ligand code = 29Q (link to the list of PDB complexes)

Download experimental 3D coordinates of 29Q with added hydrogens

DrugCentral

Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4

Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2

Download SDF file

5-(4-chlorophenyl)-2,3-dihydroimidazo[1,2-b]isoindol-5-ol

Formula:
C16H13ClN2O

Calculated chemical properties:

MW 284.73
NB_atoms 20
XLogP 2.61
PSA 33.335
NB_HD 1
NB_HA 3
fsp3 0.19
Lipinski(0=no;1=yes) 1

FDA
NDA 017247 (pdf not found) INN (MAZINDOL) SANOREX (NOVARTIS) APPROVAL= AP YEAR= 1973 DISCONTINUED
NDA 017980 (pdf not found) INN (MAZINDOL) MAZANOR (WYETH AYERST) APPROVAL= AP YEAR= 1980 DISCONTINUED