e-Drug3D
1145
BUPIVACAINE
INN
BUPIVACAINE
cas 2180-92-9
CLASS
NERVOUS SYSTEM
ANESTHETIC (LOCAL)
ACETYLCHOLINE RECEPTOR ION CHANNEL BLOCKER
ROUTE (list)
INJECTION SPINAL IMPLANTATION INFILTRATION PERIARTICULAR
PK parameters
VD 54.6 LITER
Cl 16.7 LITER / HOUR
PPB 94 PERCENT
t1/2 3.1 HOUR
Solubility
SOLUBLE IN WATER
TARGET ACETYLCHOLINE RECEPTOR
NMDA RECEPTOR
5HT3
Sodium channel protein type 4 subunit alpha UNIPROT P35499 SCN4A
Formula:
C18H28N2O
Calculated chemical properties:
MW 288.42
NB_atoms 21
XLogP 3.90
PSA 29.546
NB_HD 1
NB_HA 3
fsp3 0.61
Lipinski(0=no;1=yes) 1
NB_atoms 21
XLogP 3.90
PSA 29.546
NB_HD 1
NB_HA 3
fsp3 0.61
Lipinski(0=no;1=yes) 1
FDA
NDA 016964 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE ; EPINEPHRINE BITARTRATE) MARCAINE HYDROCHLORIDE W/ EPINEPHRINE (HOSPIRA) APPROVAL= AP YEAR= 1972 NEWMOLECULARENTITY
NDA 018053 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 1978 DISCONTINUED
NDA 018304 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) SENSORCAINE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1981
NDA 022046 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 1983
NDA 018692 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) MARCAINE (HOSPIRA) APPROVAL= AP YEAR= 1984
NDA 070552 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) SENSORCAINE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1986
NDA 070553 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) SENSORCAINE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1986
NDA 070554 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) SENSORCAINE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1986
NDA 070583 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 1987
NDA 070584 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 1987
NDA 070585 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 1987
NDA 070586 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 070587 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 070590 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 1987
NDA 070597 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 1987
NDA 070609 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 1987
NDA 070966 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE ; EPINEPHRINE BITARTRATE) SENSORCAINE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1987
NDA 070967 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE ; EPINEPHRINE BITARTRATE) SENSORCAINE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1987
NDA 070968 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE ; EPINEPHRINE BITARTRATE) SENSORCAINE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1987
NDA 071202 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) SENSORCAINE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 071810 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 1987
NDA 071165 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE ; EPINEPHRINE) BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE (HOSPIRA) APPROVAL= AP YEAR= 1988
NDA 071166 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE ; EPINEPHRINE) BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE (HOSPIRA) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 071167 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE ; EPINEPHRINE) BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE (HOSPIRA) APPROVAL= AP YEAR= 1988
NDA 071168 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE ; EPINEPHRINE) BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE (HOSPIRA) APPROVAL= AP YEAR= 1988
NDA 071169 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE ; EPINEPHRINE) BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE (HOSPIRA) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 071170 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE ; EPINEPHRINE) BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE (HOSPIRA) APPROVAL= AP YEAR= 1988
NDA 071171 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE ; EPINEPHRINE) BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE (HOSPIRA) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 019978 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE KIT (HOSPIRA) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 076012 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE PRESERVATIVE FREE (INTL MEDICATED) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 021496 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE ; LIDOCAINE HYDROCHLORIDE) DUOCAINE (AMPHASTAR PHARMS INC) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 077250 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE ; EPINEPHRINE BITARTRATE) VIVACAINE (SEPTODONT) APPROVAL= AP YEAR= 2006
NDA 022496 (pdf not found) INN (BUPIVACAINE) EXPAREL (PACIRA PHARMS INC) APPROVAL= AP YEAR= 2011
NDA 091487 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE PRESERVATIVE FREE (ONESOURCE SPECIALTY) APPROVAL= AP YEAR= 2011
NDA 091503 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (ONESOURCE SPECIALTY) APPROVAL= AP YEAR= 2011
NDA 203895 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE PRESERVATIVE FREE (EUGIA PHARMA) APPROVAL= AP YEAR= 2013
NDA 207183 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (EUGIA PHARMA) APPROVAL= AP YEAR= 2016
NDA 207266 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (BAXTER HLTHCARE CORP) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 209087 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (B BRAUN MEDICAL) APPROVAL= AP YEAR= 2019
NDA 211096 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (CIVICA) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 212822 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (HUONS) APPROVAL= AP YEAR= 2019
NDA 209511 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) XARACOLL (INNOCOLL PHARMS) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 204803 (pdf not found) INN (BUPIVACAINE) POSIMIR (INNOCOLL) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 204842 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE PRESERVATIVE FREE (HIKMA PHARMS) APPROVAL= AP YEAR= 2021
NDA 205141 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (HIKMA PHARMS) APPROVAL= AP YEAR= 2021
NDA 211988 (pdf not found) INN (BUPIVACAINE ; MELOXICAM) ZYNRELEF KIT (HERON THERAPS INC) APPROVAL= AP YEAR= 2021
NDA 216039 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (MEITHEAL) APPROVAL= AP YEAR= 2023
NDA 216040 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (MEITHEAL) APPROVAL= AP YEAR= 2023
NDA 217792 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (SOMERSET) APPROVAL= AP YEAR= 2023
NDA 217821 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (ASPIRO) APPROVAL= AP YEAR= 2024
NDA 214348 (pdf not found) INN (BUPIVACAINE) BUPIVACAINE LIPOSOME (HENGRUI PHARMA) APPROVAL= AP YEAR= 2024
NDA 016964 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE ; EPINEPHRINE BITARTRATE) MARCAINE HYDROCHLORIDE W/ EPINEPHRINE (HOSPIRA) APPROVAL= AP YEAR= 1972 NEWMOLECULARENTITY
NDA 018053 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 1978 DISCONTINUED
NDA 018304 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) SENSORCAINE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1981
NDA 022046 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 1983
NDA 018692 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) MARCAINE (HOSPIRA) APPROVAL= AP YEAR= 1984
NDA 070552 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) SENSORCAINE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1986
NDA 070553 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) SENSORCAINE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1986
NDA 070554 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) SENSORCAINE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1986
NDA 070583 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 1987
NDA 070584 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 1987
NDA 070585 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 1987
NDA 070586 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 070587 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 070590 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 1987
NDA 070597 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 1987
NDA 070609 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 1987
NDA 070966 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE ; EPINEPHRINE BITARTRATE) SENSORCAINE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1987
NDA 070967 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE ; EPINEPHRINE BITARTRATE) SENSORCAINE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1987
NDA 070968 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE ; EPINEPHRINE BITARTRATE) SENSORCAINE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1987
NDA 071202 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) SENSORCAINE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 071810 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 1987
NDA 071165 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE ; EPINEPHRINE) BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE (HOSPIRA) APPROVAL= AP YEAR= 1988
NDA 071166 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE ; EPINEPHRINE) BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE (HOSPIRA) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 071167 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE ; EPINEPHRINE) BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE (HOSPIRA) APPROVAL= AP YEAR= 1988
NDA 071168 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE ; EPINEPHRINE) BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE (HOSPIRA) APPROVAL= AP YEAR= 1988
NDA 071169 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE ; EPINEPHRINE) BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE (HOSPIRA) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 071170 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE ; EPINEPHRINE) BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE (HOSPIRA) APPROVAL= AP YEAR= 1988
NDA 071171 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE ; EPINEPHRINE) BUPIVACAINE HYDROCHLORIDE AND EPINEPHRINE (HOSPIRA) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 019978 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE KIT (HOSPIRA) APPROVAL= AP YEAR= 1992 DISCONTINUED
NDA 076012 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE PRESERVATIVE FREE (INTL MEDICATED) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 021496 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE ; LIDOCAINE HYDROCHLORIDE) DUOCAINE (AMPHASTAR PHARMS INC) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 077250 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE ; EPINEPHRINE BITARTRATE) VIVACAINE (SEPTODONT) APPROVAL= AP YEAR= 2006
NDA 022496 (pdf not found) INN (BUPIVACAINE) EXPAREL (PACIRA PHARMS INC) APPROVAL= AP YEAR= 2011
NDA 091487 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE PRESERVATIVE FREE (ONESOURCE SPECIALTY) APPROVAL= AP YEAR= 2011
NDA 091503 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (ONESOURCE SPECIALTY) APPROVAL= AP YEAR= 2011
NDA 203895 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE PRESERVATIVE FREE (EUGIA PHARMA) APPROVAL= AP YEAR= 2013
NDA 207183 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (EUGIA PHARMA) APPROVAL= AP YEAR= 2016
NDA 207266 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (BAXTER HLTHCARE CORP) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 209087 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (B BRAUN MEDICAL) APPROVAL= AP YEAR= 2019
NDA 211096 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (CIVICA) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 212822 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (HUONS) APPROVAL= AP YEAR= 2019
NDA 209511 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) XARACOLL (INNOCOLL PHARMS) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 204803 (pdf not found) INN (BUPIVACAINE) POSIMIR (INNOCOLL) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 204842 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE PRESERVATIVE FREE (HIKMA PHARMS) APPROVAL= AP YEAR= 2021
NDA 205141 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (HIKMA PHARMS) APPROVAL= AP YEAR= 2021
NDA 211988 (pdf not found) INN (BUPIVACAINE ; MELOXICAM) ZYNRELEF KIT (HERON THERAPS INC) APPROVAL= AP YEAR= 2021
NDA 216039 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (MEITHEAL) APPROVAL= AP YEAR= 2023
NDA 216040 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (MEITHEAL) APPROVAL= AP YEAR= 2023
NDA 217792 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (SOMERSET) APPROVAL= AP YEAR= 2023
NDA 217821 (pdf not found) INN (BUPIVACAINE HYDROCHLORIDE) BUPIVACAINE HYDROCHLORIDE (ASPIRO) APPROVAL= AP YEAR= 2024
NDA 214348 (pdf not found) INN (BUPIVACAINE) BUPIVACAINE LIPOSOME (HENGRUI PHARMA) APPROVAL= AP YEAR= 2024