e-Drug3D

1144

MITOTANE

INN
MITOTANE

cas 53-19-0

CLASS

ANTINEOPLASTIC
ADRENAL CYTOTOXIC AGENT
TREATMENT OF INOPERABLE ADRENAL CORTICAL CARCINOMA
STEROID AND XENOBIOTIC RECEPTOR (SXR) AGONIST (PMID23179081)

ROUTE (list)

ORAL

ATC code

L01XX23

PK parameters

F 40 PERCENT
t1/2 2124 HOUR

Target

TARGET SXR RECEPTOR

DrugCentral

Cytochrome P450 11B1, mitochondrial UNIPROT P15538 CYP11B1

Cholesterol side-chain cleavage enzyme, mitochondrial UNIPROT P05108 CYP11A1

Download SDF file

1-chloro-4-[2,2-dichloro-1-(2-chlorophenyl)ethyl]benzene

Formula:
C14H10Cl4

Calculated chemical properties:

MW 320.02
NB_atoms 18
XLogP 5.93
PSA 0
NB_HD 0
NB_HA 0
fsp3 0.14
Lipinski(0=no;1=yes) 0

FDA
NDA 016885 (pdf not found) INN (MITOTANE) LYSODREN (ESTEVE) APPROVAL= AP YEAR= 1970 NEWMOLECULARENTITY