e-Drug3D

1140

TRIMIPRAMINE

INN
TRIMIPRAMINE

cas 739-71-9

CLASS

NERVOUS SYSTEM
ANTIDEPRESSANT
ADRENERGIC UPTAKE INHIBITORS
NOREPINEPHRINE-REUPTAKE INHIBITORS

ROUTE (list)

ORAL

ATC code

N06AA06

PK parameters

VD 1040 LITER (65 KILOGRAM)
Cl 62.4 LITER / HOUR (65 KILOGRAM)
PPB 95 PERCENT
t1/2 23 HOUR

Solubility

VERY SLIGHTLY SOLUBLE IN WATER

Target

TARGET SODIUM-DEPENDENT NORADRENALINE TRANSPORTER
SODIUM-DEPENDENT SEROTONIN TRANSPORTER

DrugCentral

Sodium-dependent serotonin transporter UNIPROT P31645 SLC6A4

Sodium-dependent noradrenaline transporter UNIPROT P23975 SLC6A2

Download SDF file

3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)-N,N,2-trimethylpropan-1-amine

Formula:
C20H26N2

Calculated chemical properties:

MW 294.43
NB_atoms 22
XLogP 4.12
PSA 6.755
NB_HD 0
NB_HA 2
fsp3 0.40
Lipinski(0=no;1=yes) 1

FDA
NDA 071283 (pdf not found) INN (TRIMIPRAMINE MALEATE) TRIMIPRAMINE MALEATE (USL PHARMA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071284 (pdf not found) INN (TRIMIPRAMINE MALEATE) TRIMIPRAMINE MALEATE (USL PHARMA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 071285 (pdf not found) INN (TRIMIPRAMINE MALEATE) TRIMIPRAMINE MALEATE (USL PHARMA) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 016792 (label) INN (TRIMIPRAMINE MALEATE) SURMONTIL (TEVA WOMENS) APPROVAL= AP YEAR= 1979 DISCONTINUED
NDA 077361 (pdf not found) INN (TRIMIPRAMINE MALEATE) TRIMIPRAMINE MALEATE (ELITE LABS INC) APPROVAL= AP YEAR= 2006
NDA 208127 (pdf not found) INN (TRIMIPRAMINE MALEATE) TRIMIPRAMINE MALEATE (BRECKENRIDGE) APPROVAL= AP YEAR= 2016