e-Drug3D

1133

POLYTHIAZIDE

DISCONTINUED

INN
POLYTHIAZIDE

cas 346-18-9

CLASS

CARDIOVASCULAR
DIURETIC
ANTIHYPERTENSIVE
SODIUM CHLORIDE SYMPORTER INHIBITORS

ROUTE (list)

ORAL

ATC code

C03AA05
C03AB05

PK parameters

Solubility

INSOLUBLE IN WATER

Target

TARGET SODIUM CHLORIDE SYMPORTER

DrugCentral

Solute carrier family 12 member 3 UNIPROT P55017 SLC12A3

Download SDF file

6-chloro-2-methyl-1,1-dioxo-3-(2,2,2-trifluoroethylsulfanylmethyl)-3,4-dihydrobenzo[e][1,2,4]thiadiazine-7-sulfonamide

Formula:
C11H13ClF3N3O4S3

Calculated chemical properties:

MW 439.90
NB_atoms 25
XLogP 1.66
PSA 106.807
NB_HD 3
NB_HA 7
fsp3 0.45
Lipinski(0=no;1=yes) 1

FDA
NDA 012845 (pdf not found) INN (POLYTHIAZIDE) RENESE (PFIZER) APPROVAL= AP YEAR= 1961 DISCONTINUED
NDA 013636 (pdf not found) INN (POLYTHIAZIDE ; RESERPINE) RENESE-R (PFIZER) APPROVAL= AP YEAR= 1963 DISCONTINUED
NDA 017986 (pdf not found) INN (POLYTHIAZIDE ; PRAZOSIN HYDROCHLORIDE) MINIZIDE (PFIZER) APPROVAL= AP YEAR= 1980 DISCONTINUED