e-Drug3D

1126

cas 133-67-5

CLASS

CARDIOVASCULAR
DIURETIC
ANTIHYPERTENSIVE
SODIUM CHLORIDE SYMPORTER INHIBITORS

ROUTE (list)

ORAL

PK parameters

TARGET SODIUM CHLORIDE SYMPORTER

PDB
3ILT (CRYSTAL STRUCTURE OF THE AMPA SUBUNIT GLUR2 BOUND TO THE ALLOSTERIC MODULATOR, TRICHLORMETHIAZIDE)

Ligand code = TRU (link to the list of PDB complexes)

Download experimental 3D coordinates of TRU with added hydrogens

MW 380.66
NB_atoms 20
XLogP 0.82
PSA 117.919
NB_HD 4
NB_HA 7
fsp3 0.25
Lipinski(0=no;1=yes) 1

FDA
NDA 012972 (pdf not found) INN (RESERPINE ; TRICHLORMETHIAZIDE) METATENSIN #2 (SANOFI AVENTIS US) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 083462 (pdf not found) INN (TRICHLORMETHIAZIDE) TRICHLORMETHIAZIDE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 083967 (pdf not found) INN (TRICHLORMETHIAZIDE) TRICHLORMETHIAZIDE (IMPAX LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 085962 (pdf not found) INN (TRICHLORMETHIAZIDE) TRICHLORMETHIAZIDE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 086259 (pdf not found) INN (TRICHLORMETHIAZIDE) TRICHLORMAS (MAST MM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 012265 (pdf not found) INN (TRICHLORMETHIAZIDE) NAQUA (SCHERING) APPROVAL= AP YEAR= 1960 NEWMOLECULARENTITY DISCONTINUED
NDA 083855 (pdf not found) INN (TRICHLORMETHIAZIDE) TRICHLORMETHIAZIDE (WATSON LABS) APPROVAL= AP YEAR= 1977 DISCONTINUED
NDA 085568 (pdf not found) INN (TRICHLORMETHIAZIDE) TRICHLORMETHIAZIDE (CHARTWELL RX) APPROVAL= AP YEAR= 1977 DISCONTINUED
NDA 085630 (pdf not found) INN (TRICHLORMETHIAZIDE) TRICHLOREX (LANNETT) APPROVAL= AP YEAR= 1977 DISCONTINUED
NDA 083847 (pdf not found) INN (TRICHLORMETHIAZIDE) TRICHLORMETHIAZIDE (WATSON LABS) APPROVAL= AP YEAR= 1978 DISCONTINUED
NDA 086458 (pdf not found) INN (TRICHLORMETHIAZIDE) TRICHLORMETHIAZIDE (WATSON LABS) APPROVAL= AP YEAR= 1978 DISCONTINUED
NDA 083436 (pdf not found) INN (TRICHLORMETHIAZIDE) TRICHLOREX (LANNETT) APPROVAL= AP YEAR= 1980 DISCONTINUED
NDA 087005 (pdf not found) INN (TRICHLORMETHIAZIDE) TRICHLORMETHIAZIDE (PAR PHARM) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 087007 (pdf not found) INN (TRICHLORMETHIAZIDE) TRICHLORMETHIAZIDE (PAR PHARM) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 086171 (pdf not found) INN (TRICHLORMETHIAZIDE) TRICHLORMETHIAZIDE (SANDOZ) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 085248 (pdf not found) INN (RESERPINE ; TRICHLORMETHIAZIDE) TRICHLORMETHIAZIDE W/ RESERPINE (WATSON LABS) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 012594 (pdf not found) INN (TRICHLORMETHIAZIDE) METAHYDRIN (SANOFI AVENTIS US) APPROVAL= AP YEAR= 1988 DISCONTINUED