e-Drug3D

1117

METHOHEXITAL

INN
METHOHEXITAL

cas 151-83-7

CLASS

NERVOUS SYSTEM
HYPNOTIC
ANXIOLYTIC
ANESTHETIC
BARBITURATES
GABA ALLOSTERIC MODULATOR

ROUTE (list)

INJECTION

ATC code

N01AF01
N05CA15

PK parameters

VD 71.5 LITER (65 KILOGRAM)
Cl 46 LITER / HOUR (65 KILOGRAM)
PPB 73 PERCENT
t1/2 1.6 HOUR

Solubility

FREELY SOLUBLE IN WATER

Target

TARGET GAMMA-AMINOBUTYRIC-ACID RECEPTOR SUBUNIT ALPHA-1

DrugCentral

GABA-A receptor alpha-1,beta-3,gamma-2 UNIPROT P14867 GABRA1

Download SDF file

5-hex-3-yn-2-yl-1-methyl-5-prop-2-enyl-1,3-diazinane-2,4,6-trione

Formula:
C14H18N2O3

Calculated chemical properties:

MW 262.30
NB_atoms 19
XLogP 1.31
PSA 64.136
NB_HD 1
NB_HA 5
fsp3 0.50
Lipinski(0=no;1=yes) 1

FDA
NDA 011559 (pdf not found) INN (METHOHEXITAL SODIUM) BREVITAL SODIUM (PH HEALTH) APPROVAL= AP YEAR= 1960 NEWMOLECULARENTITY
NDA 215488 (pdf not found) INN (METHOHEXITAL SODIUM) METHOHEXITAL SODIUM (ONESOURCE SPECIALTY) APPROVAL= AP YEAR= 2024