e-Drug3D
1086
DRONEDARONE
INN
DRONEDARONE
cas 141626-36-0
CLASS
CARDIOVASCULAR
ANTIARRHYTHMIC
MULTI-CHANNEL BLOCKER THAT AFFECTS CALCIUM, POTASSIUM AND SODIUM CHANNELS
ROUTE (list)
ORAL
ATC code
C01BD07
PK parameters
F 15 PERCENT
VD 1400 LITER
Cl 140 LITER / HOUR
PPB 98 PERCENT
t1/2 16 HOUR
Solubility
PRACTICALLY INSOLUBLE IN WATER
TARGET IONIC CHANNELS
Potassium,sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 UNIPROT O60741 HCN1
Potassium,sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 UNIPROT Q9UL51 HCN2
Formula:
C31H44N2O5S
Calculated chemical properties:
MW 556.75
NB_atoms 39
XLogP 7.05
PSA 92.043
NB_HD 1
NB_HA 7
fsp3 0.52
Lipinski(0=no;1=yes) 0
NB_atoms 39
XLogP 7.05
PSA 92.043
NB_HD 1
NB_HA 7
fsp3 0.52
Lipinski(0=no;1=yes) 0
FDA
NDA 022425 (pdf not found) INN (DRONEDARONE HYDROCHLORIDE) MULTAQ (SANOFI AVENTIS US) APPROVAL= AP YEAR= 2009
NDA 205682 (pdf not found) INN (DRONEDARONE HYDROCHLORIDE) DRONEDARONE HYDROCHLORIDE (WATSON LABS INC) APPROVAL= TA YEAR= 2015
NDA 205895 (pdf not found) INN (DRONEDARONE HYDROCHLORIDE) DRONEDARONE HYDROCHLORIDE (ALKEM LABS LTD) APPROVAL= TA YEAR= 2015
NDA 205903 (pdf not found) INN (DRONEDARONE HYDROCHLORIDE) DRONEDARONE HYDROCHLORIDE (GLENMARK GENERICS) APPROVAL= TA YEAR= 2015
NDA 206649 (pdf not found) INN (DRONEDARONE) DRONEDARONE (AMNEAL PHARMS) APPROVAL= TA YEAR= 2017
NDA 205744 (pdf not found) INN (DRONEDARONE HYDROCHLORIDE) DRONEDARONE HYDROCHLORIDE (SANDOZ INC) APPROVAL= TA YEAR= 2021
NDA 210678 (pdf not found) INN (DRONEDARONE) DRONEDARONE (AUROBINDO PHARMA LTD) APPROVAL= TA YEAR= 2023
NDA 205904 (pdf not found) INN (DRONEDARONE HYDROCHLORIDE) DRONEDARONE HYDROCHLORIDE (LUPIN) APPROVAL= AP YEAR= 2024
NDA 022425 (pdf not found) INN (DRONEDARONE HYDROCHLORIDE) MULTAQ (SANOFI AVENTIS US) APPROVAL= AP YEAR= 2009
NDA 205682 (pdf not found) INN (DRONEDARONE HYDROCHLORIDE) DRONEDARONE HYDROCHLORIDE (WATSON LABS INC) APPROVAL= TA YEAR= 2015
NDA 205895 (pdf not found) INN (DRONEDARONE HYDROCHLORIDE) DRONEDARONE HYDROCHLORIDE (ALKEM LABS LTD) APPROVAL= TA YEAR= 2015
NDA 205903 (pdf not found) INN (DRONEDARONE HYDROCHLORIDE) DRONEDARONE HYDROCHLORIDE (GLENMARK GENERICS) APPROVAL= TA YEAR= 2015
NDA 206649 (pdf not found) INN (DRONEDARONE) DRONEDARONE (AMNEAL PHARMS) APPROVAL= TA YEAR= 2017
NDA 205744 (pdf not found) INN (DRONEDARONE HYDROCHLORIDE) DRONEDARONE HYDROCHLORIDE (SANDOZ INC) APPROVAL= TA YEAR= 2021
NDA 210678 (pdf not found) INN (DRONEDARONE) DRONEDARONE (AUROBINDO PHARMA LTD) APPROVAL= TA YEAR= 2023
NDA 205904 (pdf not found) INN (DRONEDARONE HYDROCHLORIDE) DRONEDARONE HYDROCHLORIDE (LUPIN) APPROVAL= AP YEAR= 2024