e-Drug3D

1075
GRAMICIDIN


INN
GRAMICIDIN
cas 1405-97-6
CLASS

RESPIRATORY
ANTIBACTERIAL
ANTIBIOTIC
FORM ION CONDUCTING CHANNELS IN LIPID BILAYER
ROUTE (list)

OPHTHALMIC

ATC code

R02AB30
PK parameters

 Target

TARGET MEMBRANES

 DrugCentral

Unknown

 Download SDF file (2R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[2-[[(2S)-2-formamido-3-methylbutanoyl]amino]acetyl]amino]propanoyl]amino]-4-methylpentanoyl]amino]propanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-methylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-N-[(2S)-1-[[(2R)-1-[[(2S)-1-[[(2R)-1-[[(2S)-1-(2-hydroxyethylamino)-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-4-methylpentanamide

Formula:
C60H92N12O10

Calculated chemical properties:

MW 1141.46
NB_atoms 82
XLogP 1.23
PSA 264.913
NB_HD 12
NB_HA 22
fsp3 0.63
Lipinski(0=no;1=yes) 0

FDA
NDA 060427 (pdf not found) INN (GRAMICIDIN ; NEOMYCIN SULFATE ; POLYMYXIN B SULFATE) NEO-POLYCIN (DOW PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 062383 (pdf not found) INN (GRAMICIDIN ; NEOMYCIN SULFATE ; POLYMYXIN B SULFATE) NEOMYCIN SULFATE AND POLYMYXIN B SULFATE GRAMICIDIN (PHARMAFAIR) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 062788 (pdf not found) INN (GRAMICIDIN ; NEOMYCIN SULFATE ; POLYMYXIN B SULFATE) NEOMYCIN AND POLYMYXIN B SULFATES AND GRAMICIDIN (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 062818 (pdf not found) INN (GRAMICIDIN ; NEOMYCIN SULFATE ; POLYMYXIN B SULFATE) NEOMYCIN AND POLYMYXIN B SULFATES AND GRAMICIDIN (IPHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 060582 (pdf not found) INN (GRAMICIDIN ; NEOMYCIN SULFATE ; POLYMYXIN B SULFATE) NEOSPORIN (MONARCH PHARMS) APPROVAL= AP YEAR= 1968
NDA 064047 (pdf not found) INN (GRAMICIDIN ; NEOMYCIN SULFATE ; POLYMYXIN B SULFATE) NEOMYCIN AND POLYMYXIN B SULFATES AND GRAMICIDIN (BAUSCH AND LOMB) APPROVAL= AP YEAR= 1996
NDA 065187 (pdf not found) INN (GRAMICIDIN ; NEOMYCIN SULFATE ; POLYMYXIN B SULFATE) NEOMYCIN AND POLYMYXIN B SULFATES AND GRAMICIDIN (AMRING PHARMS) APPROVAL= AP YEAR= 2005

 Other links:

PubChem
ChemicalProbes

U.S. repository of Clinical Trials

VigiAccess
SIDER side effects

ChemSynthesis
Patent@SureChEMBL