e-Drug3D

1074

STREPTOMYCIN

INN
STREPTOMYCIN

cas 57-92-1

CLASS

METABOLISM
MACROLIDE
TUBERCULOSTATIC
ANTIFUNGAL
ANTIBIOTIC
ANTIBACTERIAL
AMINOGLYCOSIDES
PROTEIN SYNTHESIS INHIBITOR

ROUTE (list)

INJECTION

ATC code

A07AA04
J01GA01
J04AM01
A07AA54

PK parameters

F 84 PERCENT (INTRAMUSCULAR)
VD 22 LITER (65 KILOGRAM)
Cl 3 LITER / HOUR
PPB 35 PERCENT
t1/2 4 HOUR

Solubility

SOLUBLE IN WATER

Target

TARGET RIBOSOMAL PROTEIN

PDB
1NTA (2.9 A CRYSTAL STRUCTURE OF STREPTOMYCIN RNA-APTAMER)

Ligand code = SRY (link to the list of PDB complexes)

Download experimental 3D coordinates of SRY with added hydrogens

DrugCentral

Unknown

Download SDF file

2-[(1S,2R,3R,4S,5R,6R)-5-(diaminomethylideneamino)-2-[(2R,3R,4R,5S)-3-[(2S,3S,4S,5R,6S)-4,5-dihydroxy-6-(hydroxymethyl)-3-methylaminooxan-2-yl]oxy-4-formyl-4-hydroxy-5-methyloxolan-2-yl]oxy-3,4,6-trihydroxycyclohexyl]guanidine

Formula:
C21H39N7O12

Calculated chemical properties:

MW 583.61
NB_atoms 40
XLogP -11.38
PSA 307.716
NB_HD 18
NB_HA 17
fsp3 0.86
Lipinski(0=no;1=yes) 0

FDA
NDA 060107 (pdf not found) INN (STREPTOMYCIN SULFATE) STREPTOMYCIN SULFATE (LILLY) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 060404 (pdf not found) INN (STREPTOMYCIN SULFATE) STREPTOMYCIN SULFATE (LILLY) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 060684 (pdf not found) INN (STREPTOMYCIN SULFATE) STREPTOMYCIN SULFATE (COPANOS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 060076 (pdf not found) INN (STREPTOMYCIN SULFATE) STREPTOMYCIN SULFATE (PFIZER) APPROVAL= AP YEAR= 1946 DISCONTINUED
NDA 060111 (pdf not found) INN (STREPTOMYCIN SULFATE) STREPTOMYCIN SULFATE (PFIZER) APPROVAL= AP YEAR= 1952 DISCONTINUED
NDA 064210 (label) INN (STREPTOMYCIN SULFATE) STREPTOMYCIN SULFATE (XGEN PHARMS) APPROVAL= AP YEAR= 1998