e-Drug3D

1073

cas 320-67-2

CLASS

ANTINEOPLASTIC
ANTIMETABOLITES
FAB MYELODYSPLASTIC SYNDROME
CYTOTOXIC
NUCLEOSIDE ANALOG OF CYTIDINE
HYPOMETHYLATION OF DNA AND RNA AFTER PHOSPHORYLATION BY KINASE UCK2

ROUTE (list)

INTRAVENOUS SUBCUTANEOUS ORAL

PK parameters

F 89 PERCENT
VD 76 LITER
Cl 167 LITER / HOUR
t1/2 0.68 HOUR

TARGET URIDINE-CYTIDINE KINASE 2 (UCK2)

PDB
4QD3 (CRYSTAL STRUCTURE OF PEPTIDYL-TRNA HYDROLASE FROM PSEUDOMONAS AERUGINOSA WITH 5-AZACYTIDINE AT 1.89 ANGSTROM RESOLUTION)

Ligand code = 5AE (link to the list of PDB complexes)

Download experimental 3D coordinates of 5AE with added hydrogens

MW 244.22
NB_atoms 17
XLogP -3.17
PSA 137.65
NB_HD 5
NB_HA 9
fsp3 0.62
Lipinski(0=no;1=yes) 1

FDA
NDA 050794 (pdf not found) INN (AZACITIDINE) VIDAZA (BRISTOL-MYERS) APPROVAL= AP YEAR= 2004 NEWMOLECULARENTITY
NDA 201537 (pdf not found) INN (AZACITIDINE) AZACITIDINE (DR REDDYS) APPROVAL= AP YEAR= 2013
NDA 204949 (pdf not found) INN (AZACITIDINE) AZACITIDINE (NORVIUM BIOSCIENCE) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 208216 (pdf not found) INN (AZACITIDINE) AZACITIDINE (ACTAVIS LLC) APPROVAL= AP YEAR= 2016
NDA 207518 (pdf not found) INN (AZACITIDINE) AZACITIDINE (SHILPA MEDICARE) APPROVAL= AP YEAR= 2016
NDA 207234 (pdf not found) INN (AZACITIDINE) AZACITIDINE (NATCO PHARMA LTD) APPROVAL= AP YEAR= 2017
NDA 209540 (pdf not found) INN (AZACITIDINE) AZACITIDINE (CIPLA) APPROVAL= AP YEAR= 2018
NDA 207475 (pdf not found) INN (AZACITIDINE) AZACITIDINE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2018
NDA 210748 (pdf not found) INN (AZACITIDINE) AZACITIDINE (LUPIN LTD) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 209337 (pdf not found) INN (AZACITIDINE) AZACITIDINE (EUROHLTH INTL SARL) APPROVAL= AP YEAR= 2020
NDA 212128 (pdf not found) INN (AZACITIDINE) AZACITIDINE (MEITHEAL) APPROVAL= AP YEAR= 2020
NDA 214120 (pdf not found) INN (AZACITIDINE) ONUREG (BRISTOL) APPROVAL= AP YEAR= 2020
NDA 211549 (pdf not found) INN (AZACITIDINE) AZACITIDINE (AMNEAL) APPROVAL= AP YEAR= 2022
NDA 215066 (pdf not found) INN (AZACITIDINE) AZACITIDINE (EUGIA PHARMA) APPROVAL= AP YEAR= 2022
NDA 215905 (pdf not found) INN (AZACITIDINE) AZACITIDINE (JIANGSU HANSOH PHARM) APPROVAL= AP YEAR= 2023
NDA 212580 (pdf not found) INN (AZACITIDINE) AZACITIDINE (MSN LABS PVT LTD) APPROVAL= AP YEAR= 2024
NDA 215765 (pdf not found) INN (AZACITIDINE) AZACITIDINE (HETERO LABS LTD VI) APPROVAL= AP YEAR= 2024
NDA 217453 (pdf not found) INN (AZACITIDINE) AZACITIDINE (RELIANCE LIFE) APPROVAL= AP YEAR= 2025
NDA 218751 (pdf not found) INN (AZACITIDINE) AZACITIDINE (TEVA PHARMACEUTICALS DEVELOPMENT INC) APPROVAL= TA YEAR= 2025