e-Drug3D

1072

cas 24280-93-1

CLASS

IMMUNOMODULATING AGENT
IMMUNOSUPPRESSANTS
INHIBITOR OF GUANOSINE NUCLEOTIDE SYNTHESIS
PREVENTION OF ORGAN REJECTION

ROUTE (list)

ORAL

PK parameters

F 93 PERCENT
VD 112 LITER
Cl 8.4 LITER / HOUR
PPB 98 PERCENT
t1/2 12 HOUR

TARGET INOSINE MONOPHOSPHATE DEHYDROGENASE (IMPDH)

PDB
4FXS (INOSINE 5'-MONOPHOSPHATE DEHYDROGENASE FROM VIBRIO CHOLERAE COMPLEXED WITH IMP AND MYCOPHENOLIC ACID)

Ligand code = MOA (link to the list of PDB complexes)

Download experimental 3D coordinates of MOA with added hydrogens

MW 319.32
NB_atoms 23
XLogP 1.40
PSA 94.744
NB_HD 1
NB_HA 6
fsp3 0.41
Lipinski(0=no;1=yes) 1

FDA
NDA 050791 (label) INN (MYCOPHENOLIC ACID) MYFORTIC (NOVARTIS) APPROVAL= AP YEAR= 2004
NDA 091558 (pdf not found) INN (MYCOPHENOLIC ACID) MYCOPHENOLATE SODIUM (APOTEX INC) APPROVAL= AP YEAR= 2012
NDA 091248 (pdf not found) INN (MYCOPHENOLIC ACID) MYCOPHENOLATE SODIUM (RK PHARMA) APPROVAL= AP YEAR= 2014
NDA 202720 (pdf not found) INN (MYCOPHENOLIC ACID) MYCOPHENOLATE SODIUM (TEVA PHARMS USA) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 202555 (pdf not found) INN (MYCOPHENOLIC ACID) MYCOPHENOLATE SODIUM (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2017
NDA 211173 (pdf not found) INN (MYCOPHENOLIC ACID) MYCOPHENOLATE SODIUM (CONCORD BIOTECH LTD) APPROVAL= AP YEAR= 2019
NDA 214376 (pdf not found) INN (MYCOPHENOLIC ACID) MYCOPHENOLATE SODIUM (YICHANG HUMANWELL) APPROVAL= AP YEAR= 2021
NDA 208315 (pdf not found) INN (MYCOPHENOLIC ACID) MYCOPHENOLATE SODIUM (ALKEM LABS LTD) APPROVAL= AP YEAR= 2021
NDA 214289 (pdf not found) INN (MYCOPHENOLIC ACID) MYCOPHENOLATE SODIUM (TWI PHARMS) APPROVAL= AP YEAR= 2021
NDA 214630 (pdf not found) INN (MYCOPHENOLIC ACID) MYCOPHENOLATE SODIUM (BIOCON PHARMA) APPROVAL= AP YEAR= 2021
NDA 217031 (pdf not found) INN (MYCOPHENOLIC ACID) MYCOPHENOLATE SODIUM (BIOCON PHARMA) APPROVAL= AP YEAR= 2023
NDA 216637 (pdf not found) INN (MYCOPHENOLIC ACID) MYCOPHENOLATE SODIUM (FOSUN WANBANG) APPROVAL= AP YEAR= 2024
NDA 218603 (pdf not found) INN (MYCOPHENOLIC ACID) MYCOPHENOLATE SODIUM (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2024