e-Drug3D

1071

cas 56420-45-2

CLASS

ANTINEOPLASTIC
ANTHRACYCLINES
BREAST CANCER
CYTOTOXIC
DNA HELICASE INHIBITOR
INTERCALATION TRIGGERS DNA CLEAVAGE BY TOPOISOMERASE II

ROUTE (list)

INJECTION INTRAVENOUS

PK parameters

VD 1365 LITER
Cl 69 LITER / HOUR
PPB 77 PERCENT
t1/2 31 HOUR

TARGET DNA
DNA HELICASE

PDB
2DR6 (CRYSTAL STRUCTURE OF A MULTIDRUG TRANSPORTER REVEAL A FUNCTIONALLY ROTATING MECHANISM)

Ligand code = DM2_2DR6 (link to the list of PDB complexes)

Download experimental 3D coordinates of DM2_2DR6 with added hydrogens

MW 543.51
NB_atoms 39
XLogP 0.00
PSA 191.226
NB_HD 7
NB_HA 12
fsp3 0.44
Lipinski(0=no;1=yes) 0

FDA
NDA 050778 (label) INN (EPIRUBICIN HYDROCHLORIDE) ELLENCE (PFIZER INC) APPROVAL= AP YEAR= 1999
NDA 050807 (label) INN (EPIRUBICIN HYDROCHLORIDE) EPIRUBICIN HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 065289 (pdf not found) INN (EPIRUBICIN HYDROCHLORIDE) EPIRUBICIN HYDROCHLORIDE (HIKMA) APPROVAL= AP YEAR= 2007
NDA 065331 (pdf not found) INN (EPIRUBICIN HYDROCHLORIDE) EPIRUBICIN HYDROCHLORIDE (IMPAX LABS INC) APPROVAL= AP YEAR= 2007
NDA 065343 (pdf not found) INN (EPIRUBICIN HYDROCHLORIDE) EPIRUBICIN HYDROCHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 065361 (pdf not found) INN (EPIRUBICIN HYDROCHLORIDE) EPIRUBICIN HYDROCHLORIDE (CIPLA LTD) APPROVAL= AP YEAR= 2007
NDA 065371 (pdf not found) INN (EPIRUBICIN HYDROCHLORIDE) EPIRUBICIN HYDROCHLORIDE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 065408 (pdf not found) INN (EPIRUBICIN HYDROCHLORIDE) EPIRUBICIN HYDROCHLORIDE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 065411 (pdf not found) INN (EPIRUBICIN HYDROCHLORIDE) EPIRUBICIN HYDROCHLORIDE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2007 DISCONTINUED
NDA 065445 (pdf not found) INN (EPIRUBICIN HYDROCHLORIDE) EPIRUBICIN HYDROCHLORIDE (ACTAVIS TOTOWA) APPROVAL= AP YEAR= 2008 DISCONTINUED
NDA 065339 (pdf not found) INN (EPIRUBICIN HYDROCHLORIDE) EPIRUBICIN HYDROCHLORIDE (EBEWE PHARMA) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 090163 (pdf not found) INN (EPIRUBICIN HYDROCHLORIDE) EPIRUBICIN HYDROCHLORIDE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2009
NDA 090075 (label) INN (EPIRUBICIN HYDROCHLORIDE) EPIRUBICIN HYDROCHLORIDE (HISUN PHARM HANGZHOU) APPROVAL= AP YEAR= 2010
NDA 090266 (pdf not found) INN (EPIRUBICIN HYDROCHLORIDE) EPIRUBICIN HYDROCHLORIDE (ZENNOVA) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 091599 (pdf not found) INN (EPIRUBICIN HYDROCHLORIDE) EPIRUBICIN HYDROCHLORIDE (PHARMOBEDIENT) APPROVAL= AP YEAR= 2012 DISCONTINUED