e-Drug3D

1070

DALFOPRISTIN

INN
DALFOPRISTIN

cas 112362-50-2

CLASS

ANTIINFECTIVES
ANTIBIOTIC
ANTIBACTERIAL
STREPTOGRAMINS
BACTERIAL RIBOSOME BLOCKER (EARLY PHASE OF PROTEIN SYNTHESIS)

ROUTE (list)

INJECTION INTRAVENOUS

ATC code

J01FG02

PK parameters

VD 15.6 LITER
Cl 46.8 LITER / HOUR (65 KILOGRAM)
PPB 18 PERCENT
t1/2 0.7 HOUR

Target

TARGET VIRGINIAMYCIN ACETYLTRANSFERASE D (VATD)
RIBOSOME

PDB
4U26 (CRYSTAL STRUCTURE OF THE E. COLI RIBOSOME BOUND TO DALFOPRISTIN AND QUINUPRISTIN.)

Ligand code = DOL (link to the list of PDB complexes)

Download experimental 3D coordinates of DOL with added hydrogens

DrugCentral

Unknown

Download SDF file

(12Z,17Z,19Z)-6-{[2-(diethylamino)ethane]sulfonyl}-21-hydroxy-11,19-dimethyl-10-(propan-2-yl)-9,26-dioxa-3,15,28-triazatricyclo[23.2.1.0^{3,7}]octacosa-1(27),12,17,19,25(28)-pentaene-2,8,14,23-tetrone

Formula:
C34H50N4O9S

Calculated chemical properties:

MW 690.85
NB_atoms 48
XLogP 2.27
PSA 166.718
NB_HD 2
NB_HA 13
fsp3 0.62
Lipinski(0=no;1=yes) 0

FDA
NDA 050747 (label) INN (QUINUPRISTIN ; DALFOPRISTIN) SYNERCID (KING PHARMS) APPROVAL= AP YEAR= 1999 NEWMOLECULARENTITY
NDA 050748 (label) INN (DALFOPRISTIN ; QUINUPRISTIN) SYNERCID (KING PHARMS) APPROVAL= AP YEAR= 1999