e-Drug3D

1065

FOSFOMYCIN

INN
FOSFOMYCIN

cas 23155-02-4

CLASS

ANTIINFECTIVES
ANTIBIOTIC
ANTIBACTERIAL
INHIBITOR
TREATMENT OF UNCOMPLICATED URINARY TRACT INFECTIONS

ROUTE (list)

ORAL

NATURAL MOLECULE (link)

ATC code

J01XX01
S02AA17

PK parameters

F 37 PERCENT
VD 136.1 LITER
Cl 16.9 LITER / HOUR
PPB 0 PERCENT
t1/2 5.7 HOUR

Solubility

SOLUBLE IN WATER

Target

TARGET ENOLPYRUVYL TRANSFERASE

PDB
4IR0 (CRYSTAL STRUCTURE OF METALLOTHIOL TRANSFERASE FOSB 2 FROM BACILLUS ANTHRACIS STR. AMES)

Ligand code = FCN (link to the list of PDB complexes)

Download experimental 3D coordinates of FCN with added hydrogens

DrugCentral

UDP-N-acetylglucosamine 1-carboxyvinyltransferase UNIPROT P0A749 murA

Download SDF file

[(2R,3S)-3-methyloxiran-2-yl]phosphonic acid

Formula:
C3H7O4P

Calculated chemical properties:

MW 136.04
NB_atoms 8
XLogP -1.36
PSA 70.418
NB_HD 0
NB_HA 4
fsp3 1.00
Lipinski(0=no;1=yes) 1

FDA
NDA 050717 (label) INN (FOSFOMYCIN TROMETHAMINE) MONUROL (ZAMBON SPA) APPROVAL= AP YEAR= 1996 NEWMOLECULARENTITY DISCONTINUED
NDA 212548 (pdf not found) INN (FOSFOMYCIN TROMETHAMINE) FOSFOMYCIN TROMETHAMINE (XIROMED) APPROVAL= AP YEAR= 2020
NDA 214554 (pdf not found) INN (FOSFOMYCIN TROMETHAMINE) FOSFOMYCIN TROMETHAMINE (ALKEM LABS LTD) APPROVAL= AP YEAR= 2021
NDA 211881 (pdf not found) INN (FOSFOMYCIN TROMETHAMINE) FOSFOMYCIN TROMETHAMINE (CIPLA) APPROVAL= AP YEAR= 2022
NDA 216600 (pdf not found) INN (FOSFOMYCIN TROMETHAMINE) FOSFOMYCIN TROMETHAMINE (AMNEAL) APPROVAL= AP YEAR= 2024
NDA 217187 (pdf not found) INN (FOSFOMYCIN TROMETHAMINE) FOSFOMYCIN TROMETHAMINE (PRECISION DOSE INC) APPROVAL= AP YEAR= 2025