e-Drug3D

1063

cas 96036-03-2

CLASS

ANTIINFECTIVES
ANTIBIOTIC
ANTIBACTERIAL
CARBAPENEMS
PENICILLIN-BINDING PROTEIN INHIBITOR

ROUTE (list)

INJECTION INTRAVENOUS

PK parameters

VD 19.5 LITER (65 KILOGRAM)
Cl 15.2 LITER / HOUR (65 KILOGRAM)
PPB 2 PERCENT
t1/2 1 HOUR

TARGET PENICILLIN-BINDING PROTEIN (PBP)

PDB
4EUZ (CRYSTAL STRUCTURE OF SERRATIA FONTICOLA CARBAPENEMASE SFC-1 S70A-MEROPENEM COMPLEX)

Ligand code = MEM (link to the list of PDB complexes)

Download experimental 3D coordinates of MEM with added hydrogens

MW 382.46
NB_atoms 26
XLogP -1.64
PSA 110.717
NB_HD 2
NB_HA 8
fsp3 0.71
Lipinski(0=no;1=yes) 1

FDA
NDA 050706 (label) INN (MEROPENEM) MERREM IV (PFIZER) APPROVAL= AP YEAR= 1996 DISCONTINUED
NDA 090940 (pdf not found) INN (MEROPENEM) MEROPENEM (HOSPIRA INC) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 091201 (pdf not found) INN (MEROPENEM) MEROPENEM (SANDOZ) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 091404 (pdf not found) INN (MEROPENEM) MEROPENEM (ACS DOBFAR) APPROVAL= AP YEAR= 2011
NDA 202106 (label) INN (MEROPENEM) MEROPENEM AND SODIUM CHLORIDE IN DUPLEX CONTAINER (B BRAUN MEDICAL) APPROVAL= AP YEAR= 2015
NDA 204854 (pdf not found) INN (MEROPENEM) MEROPENEM (DAEWOONG PHARM CO) APPROVAL= AP YEAR= 2015 DISCONTINUED
NDA 204139 (pdf not found) INN (MEROPENEM) MEROPENEM (ACS DOBFAR SPA) APPROVAL= AP YEAR= 2016
NDA 205883 (label) INN (MEROPENEM) MEROPENEM (AMNEAL PHARMS) APPROVAL= AP YEAR= 2016
NDA 206086 (pdf not found) INN (MEROPENEM) MEROPENEM (SAVIOR LIFETEC CORP) APPROVAL= AP YEAR= 2016
NDA 206141 (pdf not found) INN (MEROPENEM) MEROPENEM (GLAND) APPROVAL= AP YEAR= 2016
NDA 205835 (pdf not found) INN (MEROPENEM) MEROPENEM (EUGIA PHARMA) APPROVAL= AP YEAR= 2017
NDA 209776 (label) INN (MEROPENEM ; VABORBACTAM) VABOMERE (REMPEX) APPROVAL= AP YEAR= 2017
NDA 210773 (pdf not found) INN (MEROPENEM) MEROPENEM (HQ SPCLT PHARMA) APPROVAL= AP YEAR= 2019
NDA 216154 (pdf not found) INN (MEROPENEM) MEROPENEM (BROOKS STERISCIENCE) APPROVAL= AP YEAR= 2022
NDA 215212 (label) INN (MEROPENEM) MEROPENEM (HQ SPCLT PHARMA) APPROVAL= AP YEAR= 2023
NDA 216424 (pdf not found) INN (MEROPENEM) MEROPENEM (QILU) APPROVAL= AP YEAR= 2024
NDA 219084 (pdf not found) INN (MEROPENEM) MEROPENEM (BROOKS STERISCIENCE) APPROVAL= AP YEAR= 2025