e-Drug3D

1059

cas 89786-04-9

CLASS

ANTIINFECTIVES
BETA-LACTAMASE INHIBITOR

ROUTE (list)

INJECTION INTRAVENOUS

PK parameters

Tmax 1 HOUR
VD 18.2 LITER
Cl 12.3 LITER / HOUR
PPB 30 PERCENT
t1/2 1.2 HOUR

TARGET PENICILLIN-BINDING PROTEIN

PDB
1VM1 (STRUCTURE OF SHV-1 BETA-LACTAMASE INHIBITED BY TAZOBACTAM)

Ligand code = TAZ (link to the list of PDB complexes)

Download experimental 3D coordinates of TAZ with added hydrogens

MW 299.30
NB_atoms 20
XLogP -2.86
PSA 118.678
NB_HD 0
NB_HA 9
fsp3 0.60
Lipinski(0=no;1=yes) 1

FDA
NDA 050684 (label) INN (PIPERACILLIN SODIUM ; TAZOBACTAM SODIUM) ZOSYN (WYETH PHARMS) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 050750 (label) INN (PIPERACILLIN SODIUM ; TAZOBACTAM SODIUM) ZOSYN IN PLASTIC CONTAINER (BAXTER HLTHCARE CORP) APPROVAL= AP YEAR= 1998
NDA 065386 (label) INN (PIPERACILLIN SODIUM ; TAZOBACTAM SODIUM) PIPERACILLIN AND TAZOBACTAM (HOSPIRA INC) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 065446 (label) INN (PIPERACILLIN SODIUM ; TAZOBACTAM SODIUM) PIPERACILLIN AND TAZOBACTAM (HOSPIRA INC) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 065362 (pdf not found) INN (PIPERACILLIN SODIUM ; TAZOBACTAM SODIUM) PIPERACILLIN AND TAZOBACTAM (SANDOZ) APPROVAL= AP YEAR= 2010
NDA 065363 (pdf not found) INN (PIPERACILLIN SODIUM ; TAZOBACTAM SODIUM) PIPERACILLIN AND TAZOBACTAM (SANDOZ) APPROVAL= AP YEAR= 2010
NDA 065498 (pdf not found) INN (PIPERACILLIN SODIUM ; TAZOBACTAM SODIUM) PIPERACILLIN AND TAZOBACTAM (EUGIA PHARMA SPECLTS) APPROVAL= AP YEAR= 2011
NDA 065523 (pdf not found) INN (PIPERACILLIN SODIUM ; TAZOBACTAM SODIUM) PIPERACILLIN AND TAZOBACTAM (ISTITUTO BIO ITA SPA) APPROVAL= AP YEAR= 2011
NDA 090498 (pdf not found) INN (PIPERACILLIN SODIUM ; TAZOBACTAM SODIUM) PIPERACILLIN AND TAZOBACTAM (ISTITUTO BIO ITA SPA) APPROVAL= AP YEAR= 2011
NDA 065458 (pdf not found) INN (PIPERACILLIN SODIUM ; TAZOBACTAM SODIUM) PIPERACILLIN AND TAZOBACTAM (STERISCIENCE) APPROVAL= AP YEAR= 2014
NDA 203557 (pdf not found) INN (PIPERACILLIN SODIUM ; TAZOBACTAM SODIUM) PIPERACILLIN AND TAZOBACTAM (SANDOZ) APPROVAL= AP YEAR= 2014
NDA 206829 (label) INN (CEFTOLOZANE SULFATE ; TAZOBACTAM SODIUM) ZERBAXA (CUBIST PHARMS LLC) APPROVAL= AP YEAR= 2014
NDA 206996 (pdf not found) INN (PIPERACILLIN SODIUM ; TAZOBACTAM SODIUM) PIPERACILLIN AND TAZOBACTAM (WOCKHARDT BIO AG) APPROVAL= AP YEAR= 2017
NDA 207146 (pdf not found) INN (PIPERACILLIN SODIUM ; TAZOBACTAM SODIUM) PIPERACILLIN AND TAZOBACTAM (WOCKHARDT BIO AG) APPROVAL= AP YEAR= 2017
NDA 207847 (pdf not found) INN (PIPERACILLIN SODIUM ; TAZOBACTAM SODIUM) PIPERACILLIN AND TAZOBACTAM (PROVEPHARM SAS) APPROVAL= AP YEAR= 2017
NDA 207848 (pdf not found) INN (PIPERACILLIN SODIUM ; TAZOBACTAM SODIUM) PIPERACILLIN AND TAZOBACTAM (PROVEPHARM SAS) APPROVAL= AP YEAR= 2017
NDA 206204 (pdf not found) INN (PIPERACILLIN SODIUM ; TAZOBACTAM SODIUM) PIPERACILLIN AND TAZOBACTAM (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2018 DISCONTINUED
NDA 203719 (pdf not found) INN (PIPERACILLIN SODIUM ; TAZOBACTAM SODIUM) PIPERACILLIN AND TAZOBACTAM (FRESENIUS KABI) APPROVAL= AP YEAR= 2018
NDA 203720 (pdf not found) INN (PIPERACILLIN SODIUM ; TAZOBACTAM SODIUM) PIPERACILLIN AND TAZOBACTAM (FRESENIUS KABI) APPROVAL= AP YEAR= 2018
NDA 204959 (pdf not found) INN (PIPERACILLIN SODIUM ; TAZOBACTAM SODIUM) PIPERACILLIN AND TAZOBACTAM (SHANDONG) APPROVAL= AP YEAR= 2018
NDA 212287 (pdf not found) INN (PIPERACILLIN SODIUM ; TAZOBACTAM SODIUM) PIPERACILLIN AND TAZOBACTAM (ASTRAL) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 208674 (pdf not found) INN (PIPERACILLIN SODIUM ; TAZOBACTAM SODIUM) PIPERACILLIN AND TAZOBACTAM (SAGENT PHARMS INC) APPROVAL= AP YEAR= 2021
NDA 208675 (pdf not found) INN (PIPERACILLIN SODIUM ; TAZOBACTAM SODIUM) PIPERACILLIN AND TAZOBACTAM (SAGENT PHARMS INC) APPROVAL= AP YEAR= 2021
NDA 217243 (pdf not found) INN (PIPERACILLIN SODIUM ; TAZOBACTAM SODIUM) PIPERACILLIN AND TAZOBACTAM (SHANDONG) APPROVAL= AP YEAR= 2023
NDA 217409 (pdf not found) INN (PIPERACILLIN SODIUM ; TAZOBACTAM SODIUM) PIPERACILLIN AND TAZOBACTAM (EUGIA PHARMA) APPROVAL= AP YEAR= 2023
NDA 206056 (label) INN (PIPERACILLIN SODIUM ; TAZOBACTAM SODIUM) PIPERACILLIN AND TAZOBACTAM AND SODIUM CHLORIDE IN DUPLEX CONTAINER (B BRAUN MEDICAL) APPROVAL= AP YEAR= 2025