e-Drug3D

1049

CEFMETAZOLE

DISCONTINUED

INN
CEFMETAZOLE

cas 56796-20-4

CLASS

ANTIINFECTIVES
ANTIBACTERIAL
ANTIBIOTIC
CEPHALOSPORINS

ROUTE (list)

INJECTION

ATC code

J01DC09

PK parameters

VD 8.45 LITER (65 KILOGRAM)
Cl 5.85 LITER / HOUR (65 KILOGRAM)
PPB 85 PERCENT
t1/2 1.5 HOUR

Target

TARGET PENICILLIN-BINDING PROTEINS 1A/1B

DrugCentral

Bacterial penicillin-binding protein UNIPROT P02918 mrcA

Download SDF file

(6R,7S)-7-[[2-(cyanomethylsulfanyl)acetyl]amino]-7-methoxy-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Formula:
C15H17N7O5S3

Calculated chemical properties:

MW 470.56
NB_atoms 30
XLogP -2.06
PSA 153.228
NB_HD 1
NB_HA 12
fsp3 0.53
Lipinski(0=no;1=yes) 0

FDA
NDA 050637 (pdf not found) INN (CEFMETAZOLE SODIUM) ZEFAZONE (PHARMACIA AND UPJOHN) APPROVAL= AP YEAR= 1989 NEWMOLECULARENTITY DISCONTINUED
NDA 050683 (pdf not found) INN (CEFMETAZOLE SODIUM) ZEFAZONE IN PLASTIC CONTAINER (PHARMACIA AND UPJOHN) APPROVAL= AP YEAR= 1992 DISCONTINUED