e-Drug3D

1042

cas 82009-34-5

CLASS

ANTIINFECTIVES
ANTIBACTERIAL
ANTIBIOTIC
DIPEPTIDASE INHIBITOR

ROUTE (list)

INTRAVENOUS INTRAMUSCULAR INJECTION

PK parameters

F 95 PERCENT
VD 9.75 LITER (65 KILOGRAM)
Cl 8.97 LITER / HOUR (65 KILOGRAM)
PPB 40 PERCENT
t1/2 0.86 HOUR

TARGET DIPEPTIDASE 1
DEHYDROPEPTIDASE I

PDB
1ITU (HUMAN RENAL DIPEPTIDASE)

Ligand code = - (link to the list of PDB complexes)

Download experimental 3D coordinates of - with added hydrogens

MW 356.44
NB_atoms 24
XLogP -1.24
PSA 116.938
NB_HD 3
NB_HA 7
fsp3 0.69
Lipinski(0=no;1=yes) 1

FDA
NDA 050587 (pdf not found) INN (CILASTATIN SODIUM ; IMIPENEM) PRIMAXIN (MERCK) APPROVAL= AP YEAR= 1985
NDA 062756 (pdf not found) INN (CILASTATIN SODIUM ; IMIPENEM) PRIMAXIN (MERCK) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 050630 (pdf not found) INN (CILASTATIN SODIUM ; IMIPENEM) PRIMAXIN (MERCK) APPROVAL= AP YEAR= 1990 DISCONTINUED
NDA 090825 (pdf not found) INN (CILASTATIN SODIUM ; IMIPENEM) IMIPENEM AND CILASTATIN (HOSPIRA INC) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 090577 (pdf not found) INN (CILASTATIN SODIUM ; IMIPENEM) IMIPENEM AND CILASTATIN (ACS DOBFAR) APPROVAL= AP YEAR= 2011
NDA 091007 (pdf not found) INN (CILASTATIN SODIUM ; IMIPENEM) IMIPENEM AND CILASTATIN (HOSPIRA INC) APPROVAL= AP YEAR= 2011 DISCONTINUED
NDA 207594 (pdf not found) INN (CILASTATIN SODIUM ; IMIPENEM) IMIPENEM AND CILASTATIN (HQ SPCLT PHARMA) APPROVAL= AP YEAR= 2019
NDA 212819 (pdf not found) INN (CILASTATIN SODIUM ; IMIPENEM ; RELEBACTAM) RECARBRIO (MSD MERCK CO) APPROVAL= AP YEAR= 2019