e-Drug3D

1035
AMDINOCILLIN

DISCONTINUED


INN
AMDINOCILLIN

(is an active metabolite)

cas 32887-01-7
CLASS

ANTIINFECTIVES
ANTIBIOTIC
ANTIBACTERIAL
PENICILLINS
TREATMENT OF URINARY TRACT INFECTIONS
ROUTE (list)

INJECTION

ATC code

PIVMECILLINAM
PK parameters

VD 24 LITER (65 KILOGRAM)
Cl 24 LITER / HOUR (65 KILOGRAM)
PPB 25 PERCENT
t1/2 1.1 HOUR

 Target

TARGET PENICILLIN-BINDING PROTEIN 2B

PDB
6TIX (CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 2 FROM YERSINIA PESTIS IN COMPLEX WITH MECILLINAM)

Ligand code = DH4 (link to the list of PDB complexes)

Download experimental 3D coordinates of DH4 with added hydrogens

 DrugCentral

Peptidoglycan D,D-transpeptidase MrdA UNIPROT P0AD65 mrdA

 Download SDF file (2S,5R,6R)-6-(azepan-1-ylmethylideneamino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid

Formula:
C15H23N3O3S

Calculated chemical properties:

MW 324.43
NB_atoms 22
XLogP 0.07
PSA 68.741
NB_HD 0
NB_HA 6
fsp3 0.80
Lipinski(0=no;1=yes) 1

FDA
NDA 050565 (pdf not found) INN (AMDINOCILLIN) COACTIN (ROCHE) APPROVAL= - YEAR= 0 DISCONTINUED

 Other links:

PubChem
ChemicalProbes

U.S. repository of Clinical Trials

VigiAccess
SIDER side effects

ChemSynthesis
Patent@SureChEMBL