e-Drug3D

103

cas 59-05-2

CLASS

ANTINEOPLASTIC
FOLIC ACID ANTAGONISTS
IMMUNOSUPPRESSIVE AGENTS
NUCLEIC ACID SYNTHESIS INHIBITORS
ANTIMETABOLITES
TREATMENT OF SEVERE PSORIASIS AND ADULT RHEUMATOID ARTHRITIS
ANTIMALARIALS

ROUTE (list)

ORAL INJECTION SUBCUTANEOUS INTRAVENOUS

PK parameters

F 60 PERCENT
Tmax 1.5 HOUR
VD 39 LITER (65 KILOGRAM)
Cl 8.2 LITER / HOUR (65 KILOGRAM)
PPB 50 PERCENT
t1/2 7.5 HOUR

TARGET DIHYDROFOLATE REDUCTASE

PDB
5X66 (HUMAN THYMIDYLATE SYNTHASE IN COMPLEX WITH DUMP AND METHOTREXATE)

Ligand code = MTX (link to the list of PDB complexes)

Download experimental 3D coordinates of MTX with added hydrogens

MW 452.44
NB_atoms 33
XLogP -2.40
PSA 189.852
NB_HD 5
NB_HA 13
fsp3 0.25
Lipinski(0=no;1=yes) 0

FDA
NDA 087695 (pdf not found) INN (METHOTREXATE SODIUM) FOLEX (PHARMACIA AND UPJOHN) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088954 (pdf not found) INN (METHOTREXATE SODIUM) FOLEX (PHARMACIA AND UPJOHN) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089161 (pdf not found) INN (METHOTREXATE SODIUM) ABITREXATE (ABIC) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089180 (pdf not found) INN (METHOTREXATE SODIUM) FOLEX PFS (PHARMACIA AND UPJOHN) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089293 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089294 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089295 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089296 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089308 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089309 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM (QUAD PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089354 (pdf not found) INN (METHOTREXATE SODIUM) ABITREXATE (ABIC) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089355 (pdf not found) INN (METHOTREXATE SODIUM) ABITREXATE (ABIC) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089356 (pdf not found) INN (METHOTREXATE SODIUM) ABITREXATE (ABIC) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 008085 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM (STRIDES PHARMA) APPROVAL= AP YEAR= 1953 DISCONTINUED
NDA 011719 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM (HOSPIRA) APPROVAL= AP YEAR= 1959
NDA 086358 (pdf not found) INN (METHOTREXATE SODIUM) MEXATE (BRISTOL) APPROVAL= AP YEAR= 1979 DISCONTINUED
NDA 088760 (pdf not found) INN (METHOTREXATE SODIUM) MEXATE-AQ (BRISTOL MYERS) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 088648 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM (NORBROOK) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 089263 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM (ABRAXIS PHARM) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 089322 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM (ABRAXIS PHARM) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 089323 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM (ABRAXIS PHARM) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 089340 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM PRESERVATIVE FREE (HIKMA) APPROVAL= AP YEAR= 1986
NDA 089341 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM (HIKMA) APPROVAL= AP YEAR= 1986
NDA 089342 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM (HIKMA) APPROVAL= AP YEAR= 1986
NDA 089343 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM PRESERVATIVE FREE (HIKMA) APPROVAL= AP YEAR= 1986
NDA 088935 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM (ABRAXIS PHARM) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 088936 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM (ABRAXIS PHARM) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 088937 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM (ABRAXIS PHARM) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 089158 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM (PHARMACHEMIE USA) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 089887 (pdf not found) INN (METHOTREXATE SODIUM) MEXATE-AQ PRESERVED (BRISTOL MYERS SQUIBB) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 081099 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM (BARR) APPROVAL= AP YEAR= 1990
NDA 081242 (pdf not found) INN (METHOTREXATE SODIUM) FOLEX PFS (PHARMACIA AND UPJOHN) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 081235 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM (MYLAN) APPROVAL= AP YEAR= 1992
NDA 040054 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM (HIKMA) APPROVAL= AP YEAR= 1994
NDA 040233 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM (DURAMED PHARMS BARR) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 040263 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1999
NDA 040265 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE PRESERVATIVE FREE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 040266 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE PRESERVATIVE FREE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 1999
NDA 040385 (pdf not found) INN (METHOTREXATE SODIUM) TREXALL (BARR) APPROVAL= AP YEAR= 2001
NDA 040632 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM PRESERVATIVE FREE (HIKMA) APPROVAL= AP YEAR= 2005
NDA 040716 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM PRESERVATIVE FREE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2007
NDA 040767 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM PRESERVATIVE FREE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2007
NDA 040768 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM PRESERVATIVE FREE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2007
NDA 090029 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM PRESERVATIVE FREE (SANDOZ) APPROVAL= AP YEAR= 2009
NDA 090039 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM PRESERVATIVE FREE (SANDOZ) APPROVAL= AP YEAR= 2009
NDA 040843 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM PRESERVATIVE FREE (PHARMACHEMIE BV) APPROVAL= AP YEAR= 2010
NDA 040850 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM PRESERVATIVE FREE () APPROVAL= AP YEAR= 2010
NDA 040853 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM PRESERVATIVE FREE () APPROVAL= AP YEAR= 2010
NDA 200171 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE PRESERVATIVE FREE () APPROVAL= AP YEAR= 2012
NDA 201529 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM PRESERVATIVE FREE (EUGIA PHARMA SPECLTS) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 201530 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM PRESERVATIVE FREE (EXTROVIS) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 204824 (pdf not found) INN (METHOTREXATE) OTREXUP (ASSERTIO SPECLTY) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 205776 (pdf not found) INN (METHOTREXATE) RASUVO (MEDEXUS) APPROVAL= AP YEAR= 2014
NDA 201749 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM (SUN PHARM) APPROVAL= AP YEAR= 2015
NDA 207812 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM (ZYDUS PHARMS) APPROVAL= AP YEAR= 2017
NDA 208400 (pdf not found) INN (METHOTREXATE SODIUM) XATMEP (AZURITY) APPROVAL= AP YEAR= 2017
NDA 210040 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM (AMNEAL PHARMS) APPROVAL= AP YEAR= 2017 DISCONTINUED
NDA 203407 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM PRESERVATIVE FREE (SAGENT PHARMS INC) APPROVAL= AP YEAR= 2018
NDA 210737 (pdf not found) INN (METHOTREXATE) REDITREX (NORDIC GRP) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 210454 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM (EUGIA PHARMA) APPROVAL= AP YEAR= 2020
NDA 213343 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2020
NDA 214121 (pdf not found) INN (METHOTREXATE) METHOTREXATE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2020 DISCONTINUED
NDA 209787 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM (LOTUS PHARM CO LTD) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 212479 (pdf not found) INN (METHOTREXATE) JYLAMVO (SHORLA) APPROVAL= AP YEAR= 2022
NDA 213362 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM (DAITO) APPROVAL= AP YEAR= 2023
NDA 216453 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM (ELITE LABS INC) APPROVAL= AP YEAR= 2024
NDA 217552 (pdf not found) INN (METHOTREXATE SODIUM) METHOTREXATE SODIUM (ALEMBIC) APPROVAL= AP YEAR= 2024