e-Drug3D

1027

CEFOPERAZONE

DISCONTINUED

INN
CEFOPERAZONE

cas 62893-19-0

CLASS

ANTIINFECTIVES
ANTIBACTERIAL
ANTIBIOTIC
CEPHALOSPORINS

ROUTE (list)

INJECTION

ATC code

J01DD12
J01DD62

PK parameters

VD 11 LITER (65 KILOGRAM)
Cl 5 LITER / HOUR (65 KILOGRAM)
PPB 90 PERCENT
t1/2 2 HOUR

Solubility

FREELY SOLUBLE IN WATER

Target

TARGET PENICILLIN-BINDING PROTEINS 1A/1B

DrugCentral

Bacterial penicillin-binding protein UNIPROT P02918 mrcA

Download SDF file

(6R,7R)-7-[[2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-(4-hydroxyphenyl)acetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

Formula:
C25H27N9O8S2

Calculated chemical properties:

MW 644.69
NB_atoms 44
XLogP -2.45
PSA 210.863
NB_HD 3
NB_HA 17
fsp3 0.40
Lipinski(0=no;1=yes) 0

FDA
NDA 050551 (label) INN (CEFOPERAZONE SODIUM) CEFOBID (PFIZER) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 050613 (pdf not found) INN (CEFOPERAZONE SODIUM) CEFOBID IN PLASTIC CONTAINER (PFIZER) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 063333 (pdf not found) INN (CEFOPERAZONE SODIUM) CEFOBID (PFIZER) APPROVAL= AP YEAR= 1995 DISCONTINUED