e-Drug3D

1025

cas 63527-52-6

CLASS

ANTIINFECTIVES
ANTIBACTERIAL
ANTIBIOTIC
CEPHALOSPORINS

ROUTE (list)

INJECTION

PK parameters

VD 12.3 LITER (65 KILOGRAM)
Cl 10.5 LITER / HOUR (65 KILOGRAM)
PPB 40 PERCENT
t1/2 1 HOUR

TARGET PENICILLIN-BINDING PROTEINS 1A/1B
PENICILLIN-BINDING PROTEIN 3

PDB
4PM7 (CRYSTAL STRUCTURE OF CTX-M-14 S70G:S237A IN COMPLEX WITH CEFOTAXIME AT 1.29 ANGSTROMS RESOLUTION)

Ligand code = CE3 (link to the list of PDB complexes)

Download experimental 3D coordinates of CE3 with added hydrogens

MW 454.48
NB_atoms 30
XLogP -1.96
PSA 148.765
NB_HD 3
NB_HA 12
fsp3 0.38
Lipinski(0=no;1=yes) 0

FDA
NDA 050547 (label) INN (CEFOTAXIME SODIUM) CLAFORAN (STERIMAX) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 050596 (label) INN (CEFOTAXIME SODIUM) CLAFORAN IN SODIUM CHLORIDE 0.9% IN PLASTIC CONTAINER (STERIMAX) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 062659 (pdf not found) INN (CEFOTAXIME SODIUM) CLAFORAN (SANOFI AVENTIS US) APPROVAL= AP YEAR= 1987 DISCONTINUED
NDA 064200 (pdf not found) INN (CEFOTAXIME SODIUM) CEFOTAXIME (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 064201 (pdf not found) INN (CEFOTAXIME SODIUM) CEFOTAXIME (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 065071 (pdf not found) INN (CEFOTAXIME SODIUM) CEFOTAXIME (HIKMA) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 065072 (pdf not found) INN (CEFOTAXIME SODIUM) CEFOTAXIME (HIKMA) APPROVAL= AP YEAR= 2002 DISCONTINUED
NDA 065124 (pdf not found) INN (CEFOTAXIME SODIUM) CEFOTAXIME SODIUM (LUPIN) APPROVAL= AP YEAR= 2003 DISCONTINUED
NDA 050792 (label) INN (CEFOTAXIME SODIUM) CEFOTAXIME AND DEXTROSE 2.4% IN PLASTIC CONTAINER (B BRAUN) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 065197 (pdf not found) INN (CEFOTAXIME SODIUM) CEFOTAXIME (WOCKHARDT) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 065290 (pdf not found) INN (CEFOTAXIME SODIUM) CEFOTAXIME SODIUM (HOSPIRA INC) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 065292 (pdf not found) INN (CEFOTAXIME SODIUM) CEFOTAXIME SODIUM (HOSPIRA INC) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 065293 (pdf not found) INN (CEFOTAXIME SODIUM) CEFOTAXIME SODIUM (HOSPIRA INC) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 065516 (pdf not found) INN (CEFOTAXIME SODIUM) CEFOTAXIME SODIUM (AUROBINDO PHARMA LTD) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 065517 (pdf not found) INN (CEFOTAXIME SODIUM) CEFOTAXIME SODIUM (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 065348 (pdf not found) INN (CEFOTAXIME SODIUM) CEFOTAXIME SODIUM (CEPHAZONE PHARMA) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 203132 (pdf not found) INN (CEFOTAXIME SODIUM) CEFOTAXIME SODIUM (HOSPIRA) APPROVAL= AP YEAR= 2016 DISCONTINUED