e-Drug3D

1012

VIDARABINE

DISCONTINUED

INN
VIDARABINE

cas 5536-17-4

CLASS

ANTIVIRAL
ANTIMETABOLITES
AN ANTIVIRAL DRUG FOR THE TOPICAL TREATMENT OF EPITHELIAL KERATITIS CAUSED BY HERPES SIMPLEX VIRUS

ROUTE (list)

OPHTHALMIC INJECTION

ATC code

J05AB03
S01AD06

PK parameters

Target

TARGET ADENOSINE DEAMINASE
THYMIDINE KINASE
DNA
PURINE NUCLEOSIDE PHOSPHORYLASE
DNA POLYMERASE

PDB
1PW7 (CRYSTAL STRUCTURE OF E. COLI PURINE NUCLEOSIDE PHOSPHORYLASE COMPLEXED WITH 9-BETA-D-ARABINOFURANOSYLADENINE AND SULFATE, PHOSPHATE)

Ligand code = RAB (link to the list of PDB complexes)

Download experimental 3D coordinates of RAB with added hydrogens

DrugCentral

DNA polymerase catalytic subunit UNIPROT P04293

Download SDF file

(2R,3S,4S,5R)-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol hydrate

Formula:
C10H13N5O4

Calculated chemical properties:

MW 267.25
NB_atoms 19
XLogP -1.98
PSA 133.029
NB_HD 5
NB_HA 9
fsp3 0.50
Lipinski(0=no;1=yes) 1

FDA
NDA 050486 (pdf not found) INN (VIDARABINE) VIRA-A (PARKEDALE) APPROVAL= AP YEAR= 1976 NEWMOLECULARENTITY DISCONTINUED
NDA 050523 (pdf not found) INN (VIDARABINE) VIRA-A (PARKEDALE) APPROVAL= AP YEAR= 1978 DISCONTINUED