e-Drug3D

101

cas 312-48-1

CLASS

METABOLISM
ANTIDOTES
ACETYLCHOLINESTERASE INHIBITOR
REVERSAL AGENT OF NON DEPOLARIZING NEUROMUSCULAR RELAXANT

ROUTE (list)

INJECTION

PK parameters

VD 71.5 LITER (65 KILOGRAM)
Cl 37.4 LITER / HOUR (65 KILOGRAM)
t1/2 1.8 HOUR

TARGET ACETYLCHOLINESTERASE

PDB
2ACK (ACETYLCHOLINESTERASE COMPLEXED WITH EDROPHONIUM, MONOCHROMATIC DATA)

Ligand code = EDR (link to the list of PDB complexes)

Download experimental 3D coordinates of EDR with added hydrogens

MW 166.24
NB_atoms 12
XLogP 1.98
PSA 21.524
NB_HD 1
NB_HA 1
fsp3 0.40
Lipinski(0=no;1=yes) 1

FDA
NDA 040043 (pdf not found) INN (EDROPHONIUM CHLORIDE) EDROPHONIUM CHLORIDE PRESERVATIVE FREE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 040044 (pdf not found) INN (EDROPHONIUM CHLORIDE) EDROPHONIUM CHLORIDE (WATSON LABS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 007959 (pdf not found) INN (EDROPHONIUM CHLORIDE) TENSILON (PAI HOLDINGS PHARM) APPROVAL= AP YEAR= 1951 NEWMOLECULARENTITY DISCONTINUED
NDA 088873 (pdf not found) INN (EDROPHONIUM CHLORIDE) ENLON (NORVIUM BIOSCIENCE) APPROVAL= AP YEAR= 1985 DISCONTINUED
NDA 089624 (pdf not found) INN (EDROPHONIUM CHLORIDE) REVERSOL (ORGANON USA INC) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 019677 (pdf not found) INN (ATROPINE SULFATE ; EDROPHONIUM CHLORIDE) ENLON-PLUS (NORVIUM BIOSCIENCE) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 019678 (pdf not found) INN (ATROPINE SULFATE ; EDROPHONIUM CHLORIDE) ENLON-PLUS (NORVIUM BIOSCIENCE) APPROVAL= AP YEAR= 1991 DISCONTINUED
NDA 040131 (pdf not found) INN (EDROPHONIUM CHLORIDE) EDROPHONIUM CHLORIDE (HOSPIRA) APPROVAL= AP YEAR= 1998 DISCONTINUED