e-Drug3D

1004

cas 13292-46-1

CLASS

ANTIINFECTIVES
TUBERCULOSTATIC
ANTIFUNGAL
ANTIBIOTIC
ANTIBACTERIAL
LEPROSTATIC
INHIBIOR OF DNA-DEPENDENT RNA POLYMERASE ACTIVITY IN MYCOBACTERIUM TUBERCULOSIS ORGANISMS (DOES NOT INHIBIT THE MAMMALIAN ENZYME)

ROUTE (list)

ORAL INJECTION

PK parameters

Tmax 2.5 HOUR
VD 63 LITER (65 KILOGRAM)
Cl 13.6 LITER / HOUR (65 KILOGRAM)
PPB 80 PERCENT
t1/2 3.6 HOUR

TARGET DNA-DEPENDENT RNA POLYMERASE
ADP-RIBOSYL TRANSFERASE

PDB
2HW2 (CRYSTAL STRUCTURE OF RIFAMPIN ADP-RIBOSYL TRANSFERASE IN COMPLEX WITH RIFAMPIN)

Ligand code = RFP (link to the list of PDB complexes)

Download experimental 3D coordinates of RFP with added hydrogens

MW 822.93
NB_atoms 59
XLogP 4.34
PSA 197.57
NB_HD 6
NB_HA 16
fsp3 0.53
Lipinski(0=no;1=yes) 0

FDA
NDA 050420 (pdf not found) INN (RIFAMPIN) RIFADIN (SANOFI AVENTIS US) APPROVAL= AP YEAR= 1971 DISCONTINUED
NDA 050429 (pdf not found) INN (RIFAMPIN) RIMACTANE (OXFORD PHARMS) APPROVAL= AP YEAR= 1971
NDA 061884 (pdf not found) INN (ISONIAZID ; RIFAMPIN) RIFAMATE (SANOFI AVENTIS US) APPROVAL= AP YEAR= 1975 DISCONTINUED
NDA 062303 (pdf not found) INN (RIFAMPIN) RIFADIN (SANOFI AVENTIS US) APPROVAL= AP YEAR= 1981 DISCONTINUED OBSOLETE
NDA 050627 (pdf not found) INN (RIFAMPIN) RIFADIN (SANOFI AVENTIS US) APPROVAL= AP YEAR= 1989
NDA 050705 (pdf not found) INN (ISONIAZID ; PYRAZINAMIDE ; RIFAMPIN) RIFATER (SANOFI AVENTIS US) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 064150 (pdf not found) INN (RIFAMPIN) RIFAMPIN (EPIC PHARMA LLC) APPROVAL= AP YEAR= 1997
NDA 064217 (pdf not found) INN (RIFAMPIN) RIFAMPIN (HIKMA) APPROVAL= AP YEAR= 1999
NDA 065028 (pdf not found) INN (RIFAMPIN) RIFAMPIN (HIKMA) APPROVAL= AP YEAR= 2001 DISCONTINUED
NDA 065221 (pdf not found) INN (ISONIAZID ; RIFAMPIN) RIFAMPIN AND ISONIAZID (HIKMA INTL PHARMS) APPROVAL= AP YEAR= 2005 DISCONTINUED
NDA 065390 (pdf not found) INN (RIFAMPIN) RIFAMPIN (CHARTWELL MOLECULAR) APPROVAL= AP YEAR= 2008
NDA 065421 (pdf not found) INN (RIFAMPIN) RIFAMPIN (MYLAN LABS LTD) APPROVAL= AP YEAR= 2008
NDA 065502 (pdf not found) INN (RIFAMPIN) RIFAMPIN (EPIC PHARMA LLC) APPROVAL= AP YEAR= 2010
NDA 090034 (pdf not found) INN (RIFAMPIN) RIFAMPIN (LUPIN PHARMS) APPROVAL= AP YEAR= 2013
NDA 091181 (pdf not found) INN (RIFAMPIN) RIFAMPIN (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2014
NDA 204101 (pdf not found) INN (RIFAMPIN) RIFAMPIN (AVET LIFESCIENCES) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 205039 (pdf not found) INN (RIFAMPIN) RIFAMPIN (HIKMA PHARMS) APPROVAL= AP YEAR= 2016
NDA 206736 (pdf not found) INN (RIFAMPIN) RIFAMPIN (WATSON PHARMS TEVA) APPROVAL= AP YEAR= 2016 DISCONTINUED