e-Drug3D

1002

CHLORTETRACYCLINE

DISCONTINUED

INN
CHLORTETRACYCLINE

cas 57-62-5

CLASS

ANTIINFECTIVES
QUINONE
ANTIPROTOZOAL
ANTIBIOTIC
ANTIBACTERIAL
ANTIAMEBIC

ROUTE (list)

OPHTHALMIC

ATC code

A01AB21
D06AA02
J01AA03
S01AA02

PK parameters

VD 58.5 LITER (65 KILOGRAM)
Cl 7.8 LITER / HOUR (65 KILOGRAM)
PPB 48 PERCENT
t1/2 7 HOUR

Target

TARGET 30S RIBOSOMAL PROTEIN

PDB
2TCT (THE COMPLEX FORMED BETWEEN TET REPRESSOR AND TETRACYCLINE-MG2+ REVEALS MECHANISM OF ANTIBIOTIC RESISTANCE)

Ligand code = CTC (link to the list of PDB complexes)

Download experimental 3D coordinates of CTC with added hydrogens

DrugCentral

Unknown

Download SDF file

2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S,4aS,5aS,6S,12aS)-

Formula:
C22H23ClN2O8

Calculated chemical properties:

MW 478.87
NB_atoms 33
XLogP 0.44
PSA 171.17
NB_HD 7
NB_HA 10
fsp3 0.41
Lipinski(0=no;1=yes) 0

FDA
NDA 050404 (pdf not found) INN (CHLORTETRACYCLINE HYDROCHLORIDE) AUREOMYCIN (LEDERLE) APPROVAL= AP YEAR= 1950 DISCONTINUED