e-Drug3D

10

cas 50-14-6

CLASS

METABOLISM
VITAMIN D2
ANTIHYPOCALCEMIC AGENTS
TREATMENT OF HYPOPARATHYROIDISM AND REFRACTORY RICKETS ALSO KNOWN AS VITAMIN D RESISTANT RICKETS,AND FAMILIAL HYPOPHOSPHATEMIA
DIFFERENT METABOLIC FATES OF VITAMINS D2 AND D3 (PMID17023693)

ROUTE (list)

ORAL INJECTION INTRAVENOUS

PK parameters

TARGET VITAMIN D3 RECEPTOR

PDB
3CZH (CRYSTAL STRUCTURE OF CYP2R1 IN COMPLEX WITH VITAMIN D2)

Ligand code = D2V (link to the list of PDB complexes)

Download experimental 3D coordinates of D2V with added hydrogens

MW 396.63
NB_atoms 29
XLogP 7.64
PSA 21.44
NB_HD 1
NB_HA 1
fsp3 0.71
Lipinski(0=no;1=yes) 0

FDA
NDA 018933 (pdf not found) INN (ASCORBIC ACID ; BIOTIN ; CYANOCOBALAMIN ; DEXPANTHENOL ; ERGOCALCIFEROL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE ; RIBOFLAVIN 5'-PHOSPHATE SODIUM ; THIAMINE ; VITAMIN A ; VITAMIN E) M.V.I.-12 LYOPHILIZED (TELIGENT) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 080747 (pdf not found) INN (ERGOCALCIFEROL) VITAMIN D (CHASE CHEM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 080956 (pdf not found) INN (ERGOCALCIFEROL) VITAMIN D (EVERYLIFE) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 084053 (pdf not found) INN (ERGOCALCIFEROL) VITAMIN D (VITARINE) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 003444 (pdf not found) INN (ERGOCALCIFEROL) DRISDOL (ESJAY PHARMA) APPROVAL= AP YEAR= 1941
NDA 006071 (pdf not found) INN (ASCORBIC ACID ; BIOTIN ; CYANOCOBALAMIN ; DEXPANTHENOL ; ERGOCALCIFEROL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE HYDROCHLORIDE ; RIBOFLAVIN 5'-PHOSPHATE SODIUM ; THIAMINE HYDROCHLORIDE ; VITAMIN A PALMITATE ; VITAMIN E) BEROCCA PN (ROCHE) APPROVAL= AP YEAR= 1947 DISCONTINUED
NDA 008809 (label) INN (ASCORBIC ACID ; BIOTIN ; CYANOCOBALAMIN ; DEXPANTHENOL ; ERGOCALCIFEROL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE HYDROCHLORIDE ; RIBOFLAVIN 5'-PHOSPHATE SODIUM ; THIAMINE HYDROCHLORIDE ; VITAMIN A ; VITAMIN E) M.V.I.-12 ADULT (HOSPIRA) APPROVAL= AP YEAR= 1953 DISCONTINUED
NDA 080884 (pdf not found) INN (ERGOCALCIFEROL) DELTALIN (LILLY) APPROVAL= AP YEAR= 1973 DISCONTINUED
NDA 080951 (pdf not found) INN (ERGOCALCIFEROL) VITAMIN D (IMPAX LABS) APPROVAL= AP YEAR= 1973 DISCONTINUED
NDA 083102 (pdf not found) INN (ERGOCALCIFEROL) VITAMIN D (WEST WARD) APPROVAL= AP YEAR= 1973 DISCONTINUED
NDA 080825 (pdf not found) INN (ERGOCALCIFEROL) VITAMIN D (CHARTWELL MOLECULAR) APPROVAL= AP YEAR= 1974 DISCONTINUED
NDA 080704 (pdf not found) INN (ERGOCALCIFEROL) VITAMIN D (BIONPHARMA) APPROVAL= AP YEAR= 1978
NDA 018440 (pdf not found) INN (ASCORBIC ACID ; BIOTIN ; CYANOCOBALAMIN ; DEXPANTHENOL ; ERGOCALCIFEROL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE HYDROCHLORIDE ; RIBOFLAVIN 5'-PHOSPHATE SODIUM ; THIAMINE HYDROCHLORIDE ; VITAMIN A ; VITAMIN E) M.V.C. 9+3 (ABRAXIS PHARM) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 018439 (pdf not found) INN (ASCORBIC ACID ; BIOTIN ; CYANOCOBALAMIN ; DEXPANTHENOL ; ERGOCALCIFEROL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE HYDROCHLORIDE ; RIBOFLAVIN 5'-PHOSPHATE SODIUM ; THIAMINE HYDROCHLORIDE ; VITAMIN A ; VITAMIN E) MVC PLUS (WATSON LABS) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 018920 (label) INN (ASCORBIC ACID ; BIOTIN ; CYANOCOBALAMIN ; DEXPANTHENOL ; ERGOCALCIFEROL ; FOLIC ACID ; NIACINAMIDE ; PHYTONADIONE ; PYRIDOXINE HYDROCHLORIDE ; RIBOFLAVIN 5'-PHOSPHATE SODIUM ; THIAMINE HYDROCHLORIDE ; VITAMIN A ; VITAMIN E) M.V.I. PEDIATRIC (HOSPIRA) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 020176 (pdf not found) INN (ASCORBIC ACID ; BIOTIN ; CYANOCOBALAMIN ; ERGOCALCIFEROL ; FOLIC ACID ; NIACINAMIDE ; PANTOTHENIC ACID ; PHYTONADIONE ; PYRIDOXINE ; RIBOFLAVIN ; THIAMINE ; VITAMIN A PALMITATE ; VITAMIN E) VITAPED (HOSPIRA) APPROVAL= AP YEAR= 1993 DISCONTINUED
NDA 021625 (label) INN (ASCORBIC ACID ; BIOTIN ; CYANOCOBALAMIN ; DEXPANTHENOL ; ERGOCALCIFEROL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE HYDROCHLORIDE ; RIBOFLAVIN 5'-PHOSPHATE SODIUM ; THIAMINE HYDROCHLORIDE ; VITAMIN A ; VITAMIN E ; VITAMIN K) M.V.I. ADULT (HOSPIRA) APPROVAL= AP YEAR= 2004 DISCONTINUED
NDA 021643 (label) INN (ASCORBIC ACID ; BIOTIN ; CYANOCOBALAMIN ; DEXPANTHENOL ; ERGOCALCIFEROL ; FOLIC ACID ; NIACINAMIDE ; PYRIDOXINE HYDROCHLORIDE ; RIBOFLAVIN 5'-PHOSPHATE SODIUM ; THIAMINE HYDROCHLORIDE ; VITAMIN A ; VITAMIN E ; VITAMIN K) M.V.I. ADULT PHARMACY BULK PACKAGE (HOSPIRA) APPROVAL= AP YEAR= 2004 NEWAPPLICATION DISCONTINUED
NDA 040833 (pdf not found) INN (ERGOCALCIFEROL) ERGOCALCIFEROL (CHARTWELL RX) APPROVAL= AP YEAR= 2009
NDA 040865 (pdf not found) INN (ERGOCALCIFEROL) ERGOCALCIFEROL (SUN PHARM INDS INC) APPROVAL= AP YEAR= 2009 DISCONTINUED
NDA 090455 (pdf not found) INN (ERGOCALCIFEROL) ERGOCALCIFEROL (ONESOURCE SPECIALTY) APPROVAL= AP YEAR= 2010
NDA 091004 (pdf not found) INN (ERGOCALCIFEROL) ERGOCALCIFEROL (SIGMAPHARM LABS LLC) APPROVAL= AP YEAR= 2010 DISCONTINUED
NDA 204276 (pdf not found) INN (ERGOCALCIFEROL) ERGOCALCIFEROL (PURACAP PHARM LLC) APPROVAL= AP YEAR= 2018