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| 1 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ESTRADIOL (is an active metabolite) (has an active metabolite)
| ESTRADIOL |
GENITO | TRANSDERMAL VAGINAL ORAL TOPICAL INJECTION | Cmax 639.7 PICOMOLAR Tmax 1 HOUR VD 78 LITER (65 KILOGRAM) PPB 98.4 PERCENT Cl 117 LITER / HOUR (65 KILOGRAM) HT 1.7 HOUR | ESTROGEN RECEPTOR PDB 1FDU (HUMAN 17-BETA-HYDROXYSTEROID-DEHYDROGENASE TYPE 1 MUTANT H221L COMPLEXED WITH ESTRADIOL AND NADP+) LIGAND CODE = EST (link to the list of PDB complexes) Download experimental 3D coordinates of EST with added hydrogens | ESTROGEN RECEPTOR ALPHA AGONIST CHEMBL206 ESTROGEN RECEPTOR ALPHA P03372 ESTROGEN RECEPTOR HOMO SAPIENS TRANSCRIPTION FACTOR NUCLEAR RECEPTOR NR3 NR3A NR3A1 | EMA | |||
| 2 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ESTRADIOL ACETATE (has an active metabolite)
| ESTRADIOL ACETATE |
GENITO | VAGINAL ORAL | ESTROGEN RECEPTOR | ESTROGEN RECEPTOR ALPHA AGONIST CHEMBL206 ESTROGEN RECEPTOR ALPHA P03372 ESTROGEN RECEPTOR HOMO SAPIENS TRANSCRIPTION FACTOR NUCLEAR RECEPTOR NR3 NR3A NR3A1 | EMA | ||||
| 3 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ESTRADIOL CYPIONATE (has an active metabolite)
| ESTRADIOL CYPIONATE |
GENITO | INJECTION INTRAMUSCULAR | ESTROGEN RECEPTOR | ESTROGEN RECEPTOR ALPHA AGONIST CHEMBL206 ESTROGEN RECEPTOR ALPHA P03372 ESTROGEN RECEPTOR HOMO SAPIENS TRANSCRIPTION FACTOR NUCLEAR RECEPTOR NR3 NR3A NR3A1 | EMA | ||||
| 4 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ESTRADIOL VALERATE (has an active metabolite)
| ESTRADIOL VALERATE |
GENITO | INJECTION ORAL | ESTROGEN RECEPTOR | ESTROGEN RECEPTOR ALPHA AGONIST CHEMBL206 ESTROGEN RECEPTOR ALPHA P03372 ESTROGEN RECEPTOR HOMO SAPIENS TRANSCRIPTION FACTOR NUCLEAR RECEPTOR NR3 NR3A NR3A1 | EMA | ||||
| 5 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ESTRONE DISCONTINUED (is an active metabolite)
| ESTRONE | NATURAL MOLECULE (link) GENITO | INJECTION | Cmax 1.03 NANOMOLAR Tmax 4 HOUR SOLUBILITY SOLUBLE IN WATER | ESTROGEN RECEPTOR PDB 3HM1 (CRYSTAL STRUCTURE OF HUMAN ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH A GLUCOCORTICOID RECEPTOR INTERACTING PROTEIN 1 NR BOX II PEPTIDE AND ESTRONE ((8R,9S,13S,14S)-3-HYDROXY-13-METHYL-7,8,9,11,12,14,15,16-OCTAHYDRO-6H-CYCLOPENTA[A]PHENANTHREN-17-ONE)) LIGAND CODE = J3Z (link to the list of PDB complexes) Download experimental 3D coordinates of J3Z with added hydrogens | ESTROGEN RECEPTOR ALPHA AGONIST CHEMBL206 ESTROGEN RECEPTOR ALPHA P03372 ESTROGEN RECEPTOR HOMO SAPIENS TRANSCRIPTION FACTOR NUCLEAR RECEPTOR NR3 NR3A NR3A1 | EMA | |||
| 6 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| ESTROPIPATE (has an active metabolite)
| ESTROPIPATE | GENITO | ORAL VAGINAL | SOLUBILITY SOLUBLE IN WATER | ESTROGEN RECEPTOR | ESTROGEN RECEPTOR ALPHA AGONIST CHEMBL206 ESTROGEN RECEPTOR ALPHA P03372 ESTROGEN RECEPTOR HOMO SAPIENS TRANSCRIPTION FACTOR NUCLEAR RECEPTOR NR3 NR3A NR3A1 | EMA | |||
| 7 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| PRASTERONE (has an active metabolite)
| PRASTERONE |
HORMONES | VAGINAL | Cmax 15 NANOMOLAR SOLUBILITY INSOLUBLE IN WATER | HYDROXYSTEROID DEHYDROGENASES 5ALPHA-REDUCTASES AROMATASES PDB 1Q22 (CRYSTAL STRUCTURE OF HUMAN CHOLESTEROL SULFOTRANSFERASE (SULT2B1B) IN THE PRESENCE OF DHEA AND PAP) LIGAND CODE = AND (link to the list of PDB complexes) Download experimental 3D coordinates of AND with added hydrogens | Sex hormone-binding globulin P04278 (SHBG_HUMAN) | EMA | |||
| 8 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TESTOSTERONE (is an active metabolite)
| TESTOSTERONE | NATURAL MOLECULE (link) GENITO | TRANSDERMAL BUCCAL IMPLANTATION INJECTION NASAL | Cmax 31.4 NANOMOLAR Tmax 8 HOUR VD 65 LITER (65 KILOGRAM) PPB 98 PERCENT Cl 62.4 LITER / HOUR (65 KILOGRAM) HT 192 HOUR | ANDROGEN RECEPTOR PDB 1AFS (RECOMBINANT RAT LIVER 3-ALPHA-HYDROXYSTEROID DEHYDROGENASE (3-ALPHA-HSD) COMPLEXED WITH NADP AND TESTOSTERONE) LIGAND CODE = TES (link to the list of PDB complexes) Download experimental 3D coordinates of TES with added hydrogens | ANDROGEN RECEPTOR AGONIST CHEMBL1871 ANDROGEN RECEPTOR P10275 ANDROGEN RECEPTOR HOMO SAPIENS TRANSCRIPTION FACTOR NUCLEAR RECEPTOR NR3 NR3C NR3C4 | EMA | |||
| 9 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TESTOSTERONE CYPIONATE (has an active metabolite)
| TESTOSTERONE CYPIONATE | HORMONES | INJECTION INTRAMUSCULAR | SOLUBILITY INSOLUBLE IN WATER | ANDROGEN RECEPTOR | ANDROGEN RECEPTOR AGONIST CHEMBL1871 ANDROGEN RECEPTOR P10275 ANDROGEN RECEPTOR HOMO SAPIENS TRANSCRIPTION FACTOR NUCLEAR RECEPTOR NR3 NR3C NR3C4 | EMA | |||
| 10 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TESTOSTERONE ENANTHATE (has an active metabolite)
| TESTOSTERONE ENANTHATE | HORMONES | INJECTION SUBCUTANEOUS | SOLUBILITY INSOLUBLE IN WATER | ANDROGEN RECEPTOR | ANDROGEN RECEPTOR AGONIST CHEMBL1871 ANDROGEN RECEPTOR P10275 ANDROGEN RECEPTOR HOMO SAPIENS TRANSCRIPTION FACTOR NUCLEAR RECEPTOR NR3 NR3C NR3C4 | EMA | |||
| 11 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TESTOSTERONE PROPIONATE DISCONTINUED (has an active metabolite)
| TESTOSTERONE PROPIONATE | GENITO | INJECTION | ANDROGEN RECEPTOR | ANDROGEN RECEPTOR AGONIST CHEMBL1871 ANDROGEN RECEPTOR P10275 ANDROGEN RECEPTOR HOMO SAPIENS TRANSCRIPTION FACTOR NUCLEAR RECEPTOR NR3 NR3C NR3C4 | EMA | ||||
| 12 | INN | Class | Route (list) | PK parameters= Cmax; Tmax; F: bioavailability; t1/2: half-life; VD: volume of distribution; Cl: clearance; PPB: plasma protein binding;(EQN means that value was calculated using VD=(Cl*t1/2)/0.693) | Primary Target and PDB code of Protein-Drug complex | Targets from DrugCentral | Links | |||
| TESTOSTERONE UNDECANOATE (has an active metabolite)
| TESTOSTERONE UNDECANOATE | GENITO | INTRAMUSCULAR ORAL | SOLUBILITY INSOLUBLE IN WATER | ANDROGEN RECEPTOR | ANDROGEN RECEPTOR AGONIST CHEMBL1871 ANDROGEN RECEPTOR P10275 ANDROGEN RECEPTOR HOMO SAPIENS TRANSCRIPTION FACTOR NUCLEAR RECEPTOR NR3 NR3C NR3C4 | EMA | |||
