e-Drug3D

957

DORIPENEM

DISCONTINUED

INN
DORIPENEM

cas 148016-81-3

CLASS

ANTIINFECTIVES
ANTIBACTERIALS
SYNTHETIC BROAD-SPECTRUM CARBAPENEM ANTIBIOTIC
INHIBITS BACTERIAL CELL WALL BIOSYNTHESIS

ROUTE (list)

INTRAVENOUS

ATC code

J01DH04

PK parameters

Tmax 1 HOUR
Cmax 54.7 MICROMOLAR (500 MILLIGRAM)
VD 16.8 LITER
Cl 15.9 LITER / HOUR
PPB 8 PERCENT
t1/2 1 HOUR

Target

TARGET PENICILLIN-BINDING PROTEIN

PDB
6P9C (OXA-48 CARBAPANEMASE, DORIPENEM COMPLEX)

Ligand code = O6P (link to the list of PDB complexes)

Download experimental 3D coordinates of O6P with added hydrogens

DrugCentral

Bacterial penicillin-binding protein UNIPROT P02918 mrcA

Download SDF file

1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 3-[[(3S,5S)-5-[[(aminosulfonyl)amino]methyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-, (4R,5S,6S)-

Formula:
C15H24N4O6S2

Calculated chemical properties:

MW 419.51
NB_atoms 27
XLogP -2.94
PSA 167.023
NB_HD 5
NB_HA 10
fsp3 0.73
Lipinski(0=no;1=yes) 0

FDA
NDA 022106 (label) INN (DORIPENEM) DORIBAX (SHIONOGI) APPROVAL= AP YEAR= 2007 DISCONTINUED