e-Drug3D

950

cas 171228-49-2

CLASS

ANTIINFECTIVES
ANTIBIOTICS
TRYPANOCIDAL AGENTS
TRIAZOLE ANTIFUNGAL AGENT
BLOCKS THE SYNTHESIS OF ERGOSTEROL

ROUTE (list)

ORAL INTRAVENOUS

PK parameters

Tmax 4 HOUR
VD 1774 LITER
Cl 32 LITER / HOUR
PPB 98 PERCENT
t1/2 37 HOUR

TARGET LANOSTEROL 14 ALPHA-DEMETHYLASE (CYTOCHROME P450 P-45014DM)

PDB
2X2N (X-RAY STRUCTURE OF CYP51 FROM TRYPANOSOMA BRUCEI IN COMPLEX WITH POSACONAZOLE IN TWO DIFFERENT CONFORMATIONS)

Ligand code = X2N (link to the list of PDB complexes)

Download experimental 3D coordinates of X2N with added hydrogens

MW 700.79
NB_atoms 51
XLogP 4.57
PSA 109.731
NB_HD 1
NB_HA 12
fsp3 0.41
Lipinski(0=no;1=yes) 0

FDA
NDA 022003 (label) INN (POSACONAZOLE) NOXAFIL (SCHERING) APPROVAL= AP YEAR= 2006
NDA 022027 (label) INN (POSACONAZOLE) NOXAFIL (SCHERING) APPROVAL= AP YEAR= 2006 NEWAPPLICATION
NDA 205053 (label) INN (POSACONAZOLE) NOXAFIL (MERCK SHARP DOHME) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 205596 (label) INN (POSACONAZOLE) NOXAFIL (MERCK SHARP DOHME) APPROVAL= AP YEAR= 2014 DISCONTINUED
NDA 212411 (pdf not found) INN (POSACONAZOLE) POSACONAZOLE (SINOTHERAPEUTICS INC) APPROVAL= AP YEAR= 2019
NDA 208773 (pdf not found) INN (POSACONAZOLE) POSACONAZOLE (HIKMA) APPROVAL= AP YEAR= 2020
NDA 213454 (pdf not found) INN (POSACONAZOLE) POSACONAZOLE (AET PHARMA) APPROVAL= AP YEAR= 2021
NDA 214770 (label) INN (POSACONAZOLE) NOXAFIL POWDERMIX KIT (MSD MERCK CO) APPROVAL= AP YEAR= 2021
NDA 208768 (pdf not found) INN (POSACONAZOLE) POSACONAZOLE (PH HEALTH) APPROVAL= AP YEAR= 2022
NDA 212226 (pdf not found) INN (POSACONAZOLE) POSACONAZOLE (SPECGX LLC) APPROVAL= AP YEAR= 2022
NDA 212500 (pdf not found) INN (POSACONAZOLE) POSACONAZOLE (DR REDDYS) APPROVAL= AP YEAR= 2022
NDA 214476 (pdf not found) INN (POSACONAZOLE) POSACONAZOLE (BIOCON PHARMA) APPROVAL= AP YEAR= 2022
NDA 207355 (pdf not found) INN (POSACONAZOLE) POSACONAZOLE (ACTAVIS LABS FL INC) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 214321 (pdf not found) INN (POSACONAZOLE) POSACONAZOLE (HETERO LABS LTD III) APPROVAL= AP YEAR= 2022
NDA 216626 (pdf not found) INN (POSACONAZOLE) POSACONAZOLE (AMNEAL) APPROVAL= AP YEAR= 2022
NDA 211500 (pdf not found) INN (POSACONAZOLE) POSACONAZOLE (MYLAN LABS LTD) APPROVAL= AP YEAR= 2023
NDA 214842 (pdf not found) INN (POSACONAZOLE) POSACONAZOLE (EUGIA PHARMA) APPROVAL= AP YEAR= 2023
NDA 216326 (pdf not found) INN (POSACONAZOLE) POSACONAZOLE (WELDING) APPROVAL= AP YEAR= 2023
NDA 209983 (pdf not found) INN (POSACONAZOLE) POSACONAZOLE (FRESENIUS KABI USA) APPROVAL= AP YEAR= 2023
NDA 216488 (pdf not found) INN (POSACONAZOLE) POSACONAZOLE (I 3 PHARMS) APPROVAL= AP YEAR= 2023
NDA 217553 (pdf not found) INN (POSACONAZOLE) POSACONAZOLE (GLAND) APPROVAL= AP YEAR= 2023
NDA 217119 (pdf not found) INN (POSACONAZOLE) POSACONAZOLE (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2024
NDA 219057 (pdf not found) INN (POSACONAZOLE) POSACONAZOLE (ASPIRO) APPROVAL= AP YEAR= 2024
NDA 217709 (pdf not found) INN (POSACONAZOLE) POSACONAZOLE (HAINAN POLY PHARM) APPROVAL= TA YEAR= 2025
NDA 217720 (pdf not found) INN (POSACONAZOLE) POSACONAZOLE (QILU PHARM HAINAN) APPROVAL= AP YEAR= 2025
NDA 218434 (pdf not found) INN (POSACONAZOLE) POSACONAZOLE (MSN) APPROVAL= AP YEAR= 2025
NDA 213331 (pdf not found) INN (POSACONAZOLE) POSACONAZOLE (APOTEX) APPROVAL= AP YEAR= 2026