e-Drug3D

927

CONIVAPTAN

INN
CONIVAPTAN

cas 210101-16-9

CLASS

CARDIOVASCULAR
AQUARESIS PROMOTERS
DIURETICS
VASOPRESSIN RECEPTOR ANTAGONIST

ROUTE (list)

INTRAVENOUS INJECTION

ATC code

C03XA02

PK parameters

VD 49.4 LITER (65 KILOGRAM)
Cl 15.2 LITER / HOUR
PPB 99 PERCENT
t1/2 5 HOUR

Solubility

VERY SLIGHTLY SOLUBLE IN WATER

Target

TARGET VASOPRESSIN V1A RECEPTOR
VASOPRESSIN V2 RECEPTOR

DrugCentral

Vasopressin V1a receptor UNIPROT P37288 AVPR1A

Vasopressin V2 receptor UNIPROT P30518 AVPR2

Download SDF file

N-[4-(2-methyl4,5-dihydro-3H-imidazo[5,4-d][1]benzazepine-6-carbonyl)phenyl]-2-phenylbenzamide

Formula:
C32H26N4O2

Calculated chemical properties:

MW 498.57
NB_atoms 38
XLogP 6.51
PSA 67.163
NB_HD 2
NB_HA 6
fsp3 0.09
Lipinski(0=no;1=yes) 0

FDA
NDA 021697 (label) INN (CONIVAPTAN HYDROCHLORIDE) VAPRISOL (CUMBERLAND) APPROVAL= AP YEAR= 2005 NEWMOLECULARENTITY
NDA 022016 (label) INN (CONIVAPTAN HYDROCHLORIDE) VAPRISOL (CUMBERLAND PHARMS) APPROVAL= AP YEAR= 2007 NEWAPPLICATION