e-Drug3D

921

cas 19387-91-8

CLASS

ANTIINFECTIVES
ANTIPROTOZOAL
ALKYLATING AGENTS
ANTITRICHOMONAL AGENTS
FREE NITRO- RADICAL GENERATED AS A RESULT OF THE REDUCTION MAY BE RESPONSIBLE FOR THE ACTIVITY
ANTIMALARIALS
CHEMICALLY REDUCED TINIDAZOLE WAS SHOWN TO RELEASE NITRITES AND CAUSE DAMAGE TO PURIFIED BACTERIAL DNA IN VITRO

ROUTE (list)

ORAL

PK parameters

Tmax 1.6 HOUR
Cmax 193.1 MICROMOLAR
VD 50 LITER
Cl 2.34 LITER / HOUR (65 KILOGRAM)
PPB 12 PERCENT
t1/2 13.2 HOUR

MW 247.28
NB_atoms 16
XLogP 0
PSA 90.861
NB_HD 0
NB_HA 6
fsp3 0.62
Lipinski(0=no;1=yes) 1

FDA
NDA 021618 (label) INN (TINIDAZOLE) TINDAMAX (MISSION PHARMA) APPROVAL= AP YEAR= 2004 NEWMOLECULARENTITY
NDA 021681 (pdf not found) INN (TINIDAZOLE) TINDAMAX (MISSION PHARMA) APPROVAL= AP YEAR= 2004 NEWAPPLICATION
NDA 021682 (pdf not found) INN (TINIDAZOLE) TINDAMAX (MISSION PHARMA) APPROVAL= AP YEAR= 2004 NEWAPPLICATION
NDA 201172 (pdf not found) INN (TINIDAZOLE) TINIDAZOLE (HIKMA) APPROVAL= AP YEAR= 2012 DISCONTINUED
NDA 202044 (pdf not found) INN (TINIDAZOLE) TINIDAZOLE (CHARTWELL RX) APPROVAL= AP YEAR= 2012
NDA 202489 (label) INN (TINIDAZOLE) TINIDAZOLE (UNIQUE) APPROVAL= AP YEAR= 2013
NDA 203808 (pdf not found) INN (TINIDAZOLE) TINIDAZOLE (EDENBRIDGE PHARMS) APPROVAL= AP YEAR= 2015