e-Drug3D

913

cas 95635-55-5

CLASS

CARDIOVASCULAR
ANTIANGINAL
TREATMENT OF CHRONIC ANGINA
INHIBIT THE CARDIAC LATE SODIUM CURRENT
VOLTAGE-GATED NA(+) CHANNELS (NAV) INHIBITOR
ALPHA1-ADRENERGIC RECEPTOR ANTAGONIST (PMID26655634)

ROUTE (list)

ORAL

PK parameters

F 76 PERCENT
Tmax 3.5 HOUR
PPB 62 PERCENT
t1/2 7 HOUR

TARGET VOLTAGE-GATED NA(+) CHANNELS (NAV) (PMID26655634)
ALPHA1-ADRENERGIC RECEPTOR (PMID26655634)

PDB
8F6P (RAT CARDIAC SODIUM CHANNEL WITH RANOLAZINE BOUND)

Ligand code = XHO (link to the list of PDB complexes)

Download experimental 3D coordinates of XHO with added hydrogens

MW 427.53
NB_atoms 31
XLogP 2.31
PSA 74.7
NB_HD 2
NB_HA 7
fsp3 0.46
Lipinski(0=no;1=yes) 1

FDA
NDA 021526 (label) INN (RANOLAZINE) RANEXA (MENARINI INTL) APPROVAL= AP YEAR= 2006 DISCONTINUED
NDA 201046 (pdf not found) INN (RANOLAZINE) RANOLAZINE (CHARTWELL RX) APPROVAL= AP YEAR= 2013
NDA 208174 (pdf not found) INN (RANOLAZINE) RANOLAZINE (TEVA PHARMS) APPROVAL= TA YEAR= 2016
NDA 208862 (pdf not found) INN (RANOLAZINE) RANOLAZINE (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 210054 (pdf not found) INN (RANOLAZINE) RANOLAZINE (AJANTA PHARMA LTD) APPROVAL= AP YEAR= 2019
NDA 211291 (pdf not found) INN (RANOLAZINE) RANOLAZINE (CIPLA) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 211707 (pdf not found) INN (RANOLAZINE) RANOLAZINE (SUN PHARM) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 211829 (pdf not found) INN (RANOLAZINE) RANOLAZINE (SCIEGEN PHARMS) APPROVAL= AP YEAR= 2019
NDA 210188 (pdf not found) INN (RANOLAZINE) RANOLAZINE (CADILA) APPROVAL= AP YEAR= 2019
NDA 210482 (pdf not found) INN (RANOLAZINE) RANOLAZINE (ANI PHARMS) APPROVAL= AP YEAR= 2019 DISCONTINUED
NDA 211082 (pdf not found) INN (RANOLAZINE) RANOLAZINE (GLENMARK PHARMS LTD) APPROVAL= AP YEAR= 2019
NDA 211745 (pdf not found) INN (RANOLAZINE) RANOLAZINE (MICRO LABS) APPROVAL= AP YEAR= 2020
NDA 211865 (pdf not found) INN (RANOLAZINE) RANOLAZINE (SUNSHINE) APPROVAL= AP YEAR= 2020
NDA 212284 (pdf not found) INN (RANOLAZINE) RANOLAZINE (MANKIND PHARMA) APPROVAL= AP YEAR= 2020
NDA 212781 (pdf not found) INN (RANOLAZINE) RANOLAZINE (ARTHUR GRP) APPROVAL= AP YEAR= 2020
NDA 209953 (pdf not found) INN (RANOLAZINE) RANOLAZINE (ALKEM LABS LTD) APPROVAL= AP YEAR= 2020
NDA 207690 (pdf not found) INN (RANOLAZINE) RANOLAZINE (AMNEAL) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 212889 (pdf not found) INN (RANOLAZINE) RANOLAZINE (RISING) APPROVAL= AP YEAR= 2021
NDA 212930 (pdf not found) INN (RANOLAZINE) RANOLAZINE (ACCORD HLTHCARE) APPROVAL= AP YEAR= 2021 DISCONTINUED
NDA 209081 (pdf not found) INN (RANOLAZINE) RANOLAZINE (AUROBINDO PHARMA) APPROVAL= AP YEAR= 2022
NDA 212788 (pdf not found) INN (RANOLAZINE) RANOLAZINE (HETERO LABS LTD III) APPROVAL= AP YEAR= 2022
NDA 213517 (pdf not found) INN (RANOLAZINE) RANOLAZINE (I3 PHARMS) APPROVAL= AP YEAR= 2022
NDA 214035 (pdf not found) INN (RANOLAZINE) RANOLAZINE (VKT PHARMA) APPROVAL= AP YEAR= 2022
NDA 216018 (label) INN (RANOLAZINE) ASPRUZYO SPRINKLE (SPIL) APPROVAL= AP YEAR= 2022 DISCONTINUED
NDA 213083 (pdf not found) INN (RANOLAZINE) RANOLAZINE (UNICHEM) APPROVAL= AP YEAR= 2023
NDA 210668 (pdf not found) INN (RANOLAZINE) RANOLAZINE (NOVAST LABS) APPROVAL= AP YEAR= 2023
NDA 213085 (pdf not found) INN (RANOLAZINE) RANOLAZINE (PIRAMAL) APPROVAL= AP YEAR= 2023
NDA 210407 (pdf not found) INN (RANOLAZINE) RANOLAZINE (TORRENT) APPROVAL= AP YEAR= 2025 DISCONTINUED
NDA 211361 (pdf not found) INN (RANOLAZINE) RANOLAZINE (JUBILANT GENERICS) APPROVAL= AP YEAR= 2025