e-Drug3D

899

ACAMPROSATE

INN
ACAMPROSATE

cas 77337-76-9

CLASS

NERVOUS SYSTEM
MAINTENANCE OF ABSTINENCE OF ALCOHOL
CHEMICAL STRUCTURE SIMILAR TO THAT OF THE ENDOGENOUS AMINO ACID HOMOTAURINE
MAY INTERACT WITH GLUTAMATE AND GABA NEUROTRANSMITTER SYSTEMS CENTRALLY

ROUTE (list)

ORAL

ATC code

N07BB03

PK parameters

F 11 PERCENT
Tmax 5.5 HOUR
VD 90.5 LITER
Cl 2.3 LITER / HOUR (EQN)
PPB 0 PERCENT
t1/2 26.5 HOUR

Solubility

FREELY SOLUBLE IN WATER

Target

DrugCentral

GABA-A receptor alpha-1,beta-3,gamma-2 UNIPROT P14867 GABRA1

Glutamate NMDA receptor UNIPROT O15399 GRIN2D

Download SDF file

3-acetamidopropane-1-sulfonic acid

Formula:
C5H11NO4S

Calculated chemical properties:

MW 181.22
NB_atoms 11
XLogP -0.60
PSA 86.906
NB_HD 2
NB_HA 5
fsp3 0.80
Lipinski(0=no;1=yes) 1

FDA
NDA 021431 (label) INN (ACAMPROSATE CALCIUM) CAMPRAL (FOREST LABS) APPROVAL= AP YEAR= 2004 NEWMOLECULARENTITY DISCONTINUED
NDA 200143 (pdf not found) INN (ACAMPROSATE CALCIUM) ACAMPROSATE CALCIUM (BARR LABS DIV TEVA) APPROVAL= AP YEAR= 2013 DISCONTINUED
NDA 202229 (pdf not found) INN (ACAMPROSATE CALCIUM) ACAMPROSATE CALCIUM (GLENMARK PHARMS LTD) APPROVAL= AP YEAR= 2013
NDA 200142 (pdf not found) INN (ACAMPROSATE CALCIUM) ACAMPROSATE CALCIUM (MYLAN) APPROVAL= AP YEAR= 2014
NDA 205995 (pdf not found) INN (ACAMPROSATE CALCIUM) ACAMPROSATE CALCIUM (ZYDUS PHARMS) APPROVAL= AP YEAR= 2017
NDA 219904 (pdf not found) INN (ACAMPROSATE CALCIUM) ACAMPROSATE CALCIUM (BIONPHARMA) APPROVAL= AP YEAR= 2025
NDA 218984 (pdf not found) INN (ACAMPROSATE CALCIUM) ACAMPROSATE CALCIUM (APPCO) APPROVAL= AP YEAR= 2026