e-Drug3D

89

QUINIDINE


INN
QUINIDINE

cas 56-54-2
CLASS

CARDIOVASCULAR
ADRENERGIC ALPHA-1 RECEPTOR ANTAGONISTS (PMID9570190)
ANTIARRHYTHMIC AGENTS
ANTIMALARIAL SCHIZONTICIDE
P-GLYCOPROTEIN INHIBITOR
SPECIFIC INHIBITOR OF CYP2D6

ROUTE (list)

INJECTION ORAL

NATURAL MOLECULE (link)

ATC code

C01BA01
C01BA51
C01BA71

PK parameters

F 70 PERCENT
Tmax 2 HOUR
VD 162.5 LITER (65 KILOGRAM)
Cl 15.6 LITER / HOUR (65 KILOGRAM)
PPB 84 PERCENT
t1/2 7 HOUR

Solubility

SPARINGLY SOLUBLE IN WATER


Target

TARGET ADRENERGIC ALPHA-1 RECEPTOR
P-GLYCOPROTEIN

PDB
4WNU (HUMAN CYTOCHROME P450 2D6 QUINIDINE COMPLEX)

Ligand code = QDN (link to the list of PDB complexes)

Download experimental 3D coordinates of QDN with added hydrogens

DrugCentral

Sodium channel protein type 5 subunit alpha UNIPROT Q14524 SCN5A

Sodium channel alpha subunits

Download SDF file (S)-[(4S,5R,7R)-5-ethenyl-1-azabicyclo[2.2.2]octan-7-yl]-(6-methoxyquinolin-4-yl)methanol

Formula:
C20H24N2O2

Calculated chemical properties:

MW 324.41
NB_atoms 24
XLogP 3.17
PSA 45.368
NB_HD 1
NB_HA 4
fsp3 0.45
Lipinski(0=no;1=yes) 1

FDA
NDA 017917 (pdf not found) INN (QUINIDINE GLUCONATE) DURAQUIN (WARNER CHILCOTT) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 083439 (pdf not found) INN (QUINIDINE SULFATE) QUINIDINE SULFATE (EVERYLIFE) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 083576 (pdf not found) INN (QUINIDINE SULFATE) QUINORA (KEY PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 083583 (pdf not found) INN (QUINIDINE SULFATE) QUINIDINE SULFATE (HALSEY) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 083622 (pdf not found) INN (QUINIDINE SULFATE) QUINIDINE SULFATE (ELKINS SINN) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 083963 (pdf not found) INN (QUINIDINE SULFATE) QUINIDINE SULFATE (VINTAGE PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 084627 (pdf not found) INN (QUINIDINE SULFATE) QUINIDINE SULFATE (PHARMAVITE) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 084932 (pdf not found) INN (QUINIDINE SULFATE) CIN-QUIN (SOLVAY) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 085175 (pdf not found) INN (QUINIDINE SULFATE) QUINIDINE SULFATE (KING PHARMS) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 085222 (pdf not found) INN (QUINIDINE SULFATE) QUINORA (SCHERING) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 085276 (pdf not found) INN (QUINIDINE SULFATE) QUINIDINE SULFATE (KV PHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 085296 (pdf not found) INN (QUINIDINE SULFATE) CIN-QUIN (SOLVAY) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 085297 (pdf not found) INN (QUINIDINE SULFATE) CIN-QUIN (SOLVAY) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 085298 (pdf not found) INN (QUINIDINE SULFATE) CIN-QUIN (SOLVAY) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 085299 (pdf not found) INN (QUINIDINE SULFATE) CIN-QUIN (SOLVAY) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 085322 (pdf not found) INN (QUINIDINE SULFATE) QUINIDINE SULFATE (PERRIGO) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 085978 (pdf not found) INN (QUINIDINE GLUCONATE) QUINACT (BAYER HLTHCARE) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 086099 (pdf not found) INN (QUINIDINE GLUCONATE) QUINACT (BAYER HLTHCARE) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 086176 (pdf not found) INN (QUINIDINE SULFATE) QUINIDINE SULFATE (LEDERLE) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088582 (pdf not found) INN (QUINIDINE GLUCONATE) QUINIDINE GLUCONATE (ASCOT) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 088973 (pdf not found) INN (QUINIDINE SULFATE) QUINIDINE SULFATE (SUPERPHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089164 (pdf not found) INN (QUINIDINE GLUCONATE) QUINIDINE GLUCONATE (SUPERPHARM) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 089476 (pdf not found) INN (QUINIDINE GLUCONATE) QUINIDINE GLUCONATE (HALSEY) APPROVAL= - YEAR= 0 DISCONTINUED
NDA 007529 (pdf not found) INN (QUINIDINE GLUCONATE) QUINIDINE GLUCONATE (LILLY) APPROVAL= AP YEAR= 1950 DISCONTINUED
NDA 012796 (label) INN (QUINIDINE SULFATE) QUINIDEX (WYETH PHARMS INC) APPROVAL= AP YEAR= 1962 DISCONTINUED
NDA 016647 (pdf not found) INN (QUINIDINE GLUCONATE) QUINAGLUTE (BAYER HLTHCARE) APPROVAL= AP YEAR= 1969 DISCONTINUED
NDA 083640 (pdf not found) INN (QUINIDINE SULFATE) QUINIDINE SULFATE (CYCLE) APPROVAL= AP YEAR= 1975 DISCONTINUED
NDA 083288 (pdf not found) INN (QUINIDINE SULFATE) QUINIDINE SULFATE (WATSON LABS) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 083347 (pdf not found) INN (QUINIDINE SULFATE) QUINIDINE SULFATE (IMPAX LABS) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 083862 (pdf not found) INN (QUINIDINE SULFATE) QUINIDINE SULFATE (HIKMA) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 083879 (pdf not found) INN (QUINIDINE SULFATE) QUINIDINE SULFATE (WARNER CHILCOTT) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 084003 (pdf not found) INN (QUINIDINE SULFATE) QUINIDINE SULFATE (PUREPAC PHARM) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 084177 (pdf not found) INN (QUINIDINE SULFATE) QUINIDINE SULFATE (BARR) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 084549 (pdf not found) INN (QUINIDINE SULFATE) QUINIDINE SULFATE (IVAX SUB TEVA PHARMS) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 084631 (pdf not found) INN (QUINIDINE SULFATE) QUINIDINE SULFATE (SANDOZ) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 085038 (pdf not found) INN (QUINIDINE SULFATE) QUINIDINE SULFATE (LILLY) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 085103 (pdf not found) INN (QUINIDINE SULFATE) QUINIDINE SULFATE (LILLY) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 085140 (pdf not found) INN (QUINIDINE SULFATE) QUINIDINE SULFATE (WATSON LABS) APPROVAL= AP YEAR= 1976 DISCONTINUED
NDA 083393 (pdf not found) INN (QUINIDINE SULFATE) QUINIDINE SULFATE (VALEANT PHARM INTL) APPROVAL= AP YEAR= 1977 DISCONTINUED
NDA 083743 (pdf not found) INN (QUINIDINE SULFATE) QUINIDINE SULFATE (CHARTWELL MOLECULAR) APPROVAL= AP YEAR= 1977 DISCONTINUED
NDA 083808 (pdf not found) INN (QUINIDINE SULFATE) QUINIDINE SULFATE (CONTRACT PHARMACAL) APPROVAL= AP YEAR= 1977 DISCONTINUED
NDA 084914 (pdf not found) INN (QUINIDINE SULFATE) QUINIDINE SULFATE (SANDOZ) APPROVAL= AP YEAR= 1977 DISCONTINUED
NDA 085068 (pdf not found) INN (QUINIDINE SULFATE) QUINIDINE SULFATE (SCHERER LABS) APPROVAL= AP YEAR= 1977 DISCONTINUED
NDA 085632 (pdf not found) INN (QUINIDINE SULFATE) QUINIDINE SULFATE (CYCLE) APPROVAL= AP YEAR= 1977 DISCONTINUED
NDA 085444 (pdf not found) INN (QUINIDINE SULFATE) QUINIDINE SULFATE (WHITEWORTH TOWN PLSN) APPROVAL= AP YEAR= 1978 DISCONTINUED
NDA 087011 (pdf not found) INN (QUINIDINE SULFATE) QUINIDINE SULFATE (DAVA PHARMS INC) APPROVAL= AP YEAR= 1979 DISCONTINUED
NDA 085583 (pdf not found) INN (QUINIDINE SULFATE) QUINIDINE SULFATE (WATSON LABS) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 085584 (pdf not found) INN (QUINIDINE SULFATE) QUINIDINE SULFATE (WATSON LABS) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 087448 (pdf not found) INN (QUINIDINE GLUCONATE) QUINATIME (WATSON LABS) APPROVAL= AP YEAR= 1981 DISCONTINUED
NDA 087810 (pdf not found) INN (QUINIDINE GLUCONATE) QUINIDINE GLUCONATE (ANI PHARMS) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 087837 (pdf not found) INN (QUINIDINE SULFATE) QUINIDINE SULFATE (USL PHARMA) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 087909 (pdf not found) INN (QUINIDINE SULFATE) QUINIDINE SULFATE (VANGARD) APPROVAL= AP YEAR= 1982 DISCONTINUED
NDA 087785 (pdf not found) INN (QUINIDINE GLUCONATE) QUINIDINE GLUCONATE (WATSON LABS) APPROVAL= AP YEAR= 1983 DISCONTINUED
NDA 088072 (pdf not found) INN (QUINIDINE SULFATE) QUINIDINE SULFATE (EPIC PHARMA LLC) APPROVAL= AP YEAR= 1983
NDA 088431 (pdf not found) INN (QUINIDINE GLUCONATE) QUINIDINE GLUCONATE (CYCLE) APPROVAL= AP YEAR= 1984 DISCONTINUED
NDA 088081 (pdf not found) INN (QUINIDINE GLUCONATE) QUINALAN (CHARTWELL MOLECULAR) APPROVAL= AP YEAR= 1986 DISCONTINUED
NDA 089338 (label) INN (QUINIDINE GLUCONATE) QUINIDINE GLUCONATE (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1987
NDA 089839 (pdf not found) INN (QUINIDINE SULFATE) QUINIDINE SULFATE (CHARTWELL RX) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 089894 (pdf not found) INN (QUINIDINE GLUCONATE) QUINIDINE GLUCONATE (RISING) APPROVAL= AP YEAR= 1988 DISCONTINUED
NDA 081029 (pdf not found) INN (QUINIDINE SULFATE) QUINIDINE SULFATE (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 081030 (pdf not found) INN (QUINIDINE SULFATE) QUINIDINE SULFATE (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 081031 (pdf not found) INN (QUINIDINE SULFATE) QUINIDINE SULFATE (SUN PHARM INDUSTRIES) APPROVAL= AP YEAR= 1989 DISCONTINUED
NDA 040045 (pdf not found) INN (QUINIDINE SULFATE) QUINIDINE SULFATE (COSETTE PHARMS NC) APPROVAL= AP YEAR= 1994 DISCONTINUED
NDA 011642 (label) INN (QUINIDINE POLYGALACTURONATE) CARDIOQUIN (PHARM RES ASSOC) APPROVAL= AP YEAR= 1999 DISCONTINUED
NDA 021879 (label) INN (DEXTROMETHORPHAN HYDROBROMIDE ; QUINIDINE SULFATE) NUEDEXTA (OTSUKA AMERICA PHARM) APPROVAL= AP YEAR= 2010
NDA 202993 (pdf not found) INN (DEXTROMETHORPHAN HYDROBROMIDE ; QUINIDINE SULFATE) DEXTROMETHORPHAN HYDROBROMIDE AND QUINIDINE SULFATE (PAR PHARM INC) APPROVAL= TA YEAR= 2015
NDA 202934 (pdf not found) INN (DEXTROMETHORPHAN HYDROBROMIDE ; QUINIDINE SULFATE) DEXTROMETHORPHAN HYDROBROMIDE AND QUINIDINE SULFATE (ACTAVIS ELIZABETH) APPROVAL= AP YEAR= 2017
NDA 212589 (pdf not found) INN (QUINIDINE GLUCONATE) QUINIDINE GLUCONATE (HIBROW HLTHCARE) APPROVAL= AP YEAR= 2021
NDA 218426 (pdf not found) INN (DEXTROMETHORPHAN HYDROBROMIDE ; QUINIDINE SULFATE) DEXTROMETHORPHAN HYDROBROMIDE AND QUINIDINE SULFATE (HETERO LABS LTD III) APPROVAL= AP YEAR= 2024
NDA 204196 (pdf not found) INN (DEXTROMETHORPHAN HYDROBROMIDE ; QUINIDINE SULFATE) DEXTROMETHORPHAN HYDROBROMIDE AND QUINIDINE SULFATE (SUN PHARM) APPROVAL= AP YEAR= 2026

Other links:

PubChem
ChemicalProbes

U.S. repository of Clinical Trials

VigiAccess
SIDER side effects

ChemSynthesis
Patent@SureChEMBL