e-Drug3D

881

PIMECROLIMUS

INN
PIMECROLIMUS

cas 137071-32-0

CLASS

DERMATOLOGICALS
IMMUNOSUPPRESSANT
ANTIINFLAMMATORY
TREATMENT OF ATOPIC DERMATITIS

ROUTE (list)

TOPICAL

ATC code

D11AH02

PK parameters

Tmax 4 HOUR
Cmax 1.72 NANOMOLAR
PPB 99.5 PERCENT

Solubility

INSOLUBLE IN WATER

Target

TARGET MACROPHILIN-12 (FKBP-12)

DrugCentral

Peptidyl-prolyl cis-trans isomerase FKBP1A UNIPROT P62942 FKBP1A

Download SDF file

(3S,4R,5S,8R,9E,12S,14S,15R,16S,18R,19R,26aS)-3-{(E)-2-[(1R,3R,4S)-4-Chloro-3-methoxycyclohexyl]-1-methylvinyl}-8-ethyl-5,6,8,11,12,13,14,15,16,17,18,19,24,25,26,26a-hexadecahydro-5,19-dihydroxy-14,16-dimethoxy-4,10,12,18-tetramethyl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)-tetrone

Formula:
C43H68ClNO11

Calculated chemical properties:

MW 810.43
NB_atoms 56
XLogP 5.72
PSA 141.283
NB_HD 2
NB_HA 12
fsp3 0.81
Lipinski(0=no;1=yes) 0

FDA
NDA 021302 (label) INN (PIMECROLIMUS) ELIDEL (BAUSCH) APPROVAL= AP YEAR= 2001 NEWMOLECULARENTITY
NDA 209345 (pdf not found) INN (PIMECROLIMUS) PIMECROLIMUS (ACTAVIS LABS UT INC) APPROVAL= AP YEAR= 2018
NDA 211769 (pdf not found) INN (PIMECROLIMUS) PIMECROLIMUS (GLENMARK PHARMS LTD) APPROVAL= AP YEAR= 2019