e-Drug3D
870
LOPINAVIR
INN
LOPINAVIR
cas 192725-17-0
CLASS
ANTIINFECTIVES
ANTIVIRAL
ANTI-HIV
HIV PROTEASE INHIBITORS
ROUTE (list)
ORAL
ATC code
J05AR10
PK parameters
Tmax 4 HOUR
Cmax 15.6 MICROMOLAR
Cl 5.98 LITER / HOUR
PPB 98.5 PERCENT
t1/2 5.5 HOUR
Solubility
PRACTICALLY INSOLUBLE IN WATER
TARGET HIV-1 PROTEASE
PDB
2O4S (CRYSTAL STRUCTURE OF HIV-1 PROTEASE (Q7K) IN COMPLEX WITH LOPINAVIR)
Ligand code = AB1 (link to the list of PDB complexes)
Download experimental 3D coordinates of AB1 with added hydrogens
Pol polyprotein UNIPROT Q72874 pol
Formula:
C37H48N4O5
Calculated chemical properties:
MW 628.79
NB_atoms 46
XLogP 4.33
PSA 97.542
NB_HD 4
NB_HA 9
fsp3 0.43
Lipinski(0=no;1=yes) 0
NB_atoms 46
XLogP 4.33
PSA 97.542
NB_HD 4
NB_HA 9
fsp3 0.43
Lipinski(0=no;1=yes) 0
FDA
NDA 021226 (label) INN (LOPINAVIR ; RITONAVIR) KALETRA (ABBVIE) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 021251 (label) INN (LOPINAVIR ; RITONAVIR) KALETRA (ABBVIE) APPROVAL= AP YEAR= 2000
NDA 021906 (label) INN (LOPINAVIR ; RITONAVIR) KALETRA (ABBVIE) APPROVAL= AP YEAR= 2005
NDA 090371 (pdf not found) INN (LOPINAVIR ; RITONAVIR) LOPINAVIR; RITONAVIR (CIPLA LIMITED) APPROVAL= TA YEAR= 2009
NDA 090471 (pdf not found) INN (LOPINAVIR ; RITONAVIR) LOPINAVIR; RITONAVIR (AUROBINDO PHARMA LTD) APPROVAL= TA YEAR= 2009
NDA 091202 (label) INN (LOPINAVIR ; RITONAVIR) LOPINAVIR; RITONAVIR (MYLAN PHARMA) APPROVAL= TA YEAR= 2011
NDA 091203 (pdf not found) INN (LOPINAVIR ; RITONAVIR) LOPINAVIR; RITONAVIR (CIPLA LIMITED) APPROVAL= TA YEAR= 2012
NDA 205425 (pdf not found) INN (LOPINAVIR ; RITONAVIR) LOPINAVIR AND RITONAVIR (CIPLA LTD) APPROVAL= TA YEAR= 2015
NDA 207407 (label) INN (LOPINAVIR ; RITONAVIR) LOPINAVIR AND RITONAVIR (LANNETT CO INC) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 091677 (pdf not found) INN (LOPINAVIR ; RITONAVIR) LOPINAVIR AND RITONAVIR (HETERO LABS LTD III) APPROVAL= AP YEAR= 2021
NDA 213857 (pdf not found) INN (LOPINAVIR ; RITONAVIR) LOPINAVIR AND RITONAVIR (LAURUS) APPROVAL= AP YEAR= 2022
NDA 079074 (pdf not found) INN (LOPINAVIR ; RITONAVIR) LOPINAVIR AND RITONAVIR (MYLAN LABS LTD) APPROVAL= AP YEAR= 2024
NDA 204739 (pdf not found) INN (LOPINAVIR ; RITONAVIR) LOPINAVIR AND RITONAVIR (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2024
NDA 214696 (pdf not found) INN (LOPINAVIR ; RITONAVIR) LOPINAVIR AND RITONAVIR (MICRO LABS) APPROVAL= AP YEAR= 2025
NDA 021226 (label) INN (LOPINAVIR ; RITONAVIR) KALETRA (ABBVIE) APPROVAL= AP YEAR= 2000 DISCONTINUED
NDA 021251 (label) INN (LOPINAVIR ; RITONAVIR) KALETRA (ABBVIE) APPROVAL= AP YEAR= 2000
NDA 021906 (label) INN (LOPINAVIR ; RITONAVIR) KALETRA (ABBVIE) APPROVAL= AP YEAR= 2005
NDA 090371 (pdf not found) INN (LOPINAVIR ; RITONAVIR) LOPINAVIR; RITONAVIR (CIPLA LIMITED) APPROVAL= TA YEAR= 2009
NDA 090471 (pdf not found) INN (LOPINAVIR ; RITONAVIR) LOPINAVIR; RITONAVIR (AUROBINDO PHARMA LTD) APPROVAL= TA YEAR= 2009
NDA 091202 (label) INN (LOPINAVIR ; RITONAVIR) LOPINAVIR; RITONAVIR (MYLAN PHARMA) APPROVAL= TA YEAR= 2011
NDA 091203 (pdf not found) INN (LOPINAVIR ; RITONAVIR) LOPINAVIR; RITONAVIR (CIPLA LIMITED) APPROVAL= TA YEAR= 2012
NDA 205425 (pdf not found) INN (LOPINAVIR ; RITONAVIR) LOPINAVIR AND RITONAVIR (CIPLA LTD) APPROVAL= TA YEAR= 2015
NDA 207407 (label) INN (LOPINAVIR ; RITONAVIR) LOPINAVIR AND RITONAVIR (LANNETT CO INC) APPROVAL= AP YEAR= 2016 DISCONTINUED
NDA 091677 (pdf not found) INN (LOPINAVIR ; RITONAVIR) LOPINAVIR AND RITONAVIR (HETERO LABS LTD III) APPROVAL= AP YEAR= 2021
NDA 213857 (pdf not found) INN (LOPINAVIR ; RITONAVIR) LOPINAVIR AND RITONAVIR (LAURUS) APPROVAL= AP YEAR= 2022
NDA 079074 (pdf not found) INN (LOPINAVIR ; RITONAVIR) LOPINAVIR AND RITONAVIR (MYLAN LABS LTD) APPROVAL= AP YEAR= 2024
NDA 204739 (pdf not found) INN (LOPINAVIR ; RITONAVIR) LOPINAVIR AND RITONAVIR (MACLEODS PHARMS LTD) APPROVAL= AP YEAR= 2024
NDA 214696 (pdf not found) INN (LOPINAVIR ; RITONAVIR) LOPINAVIR AND RITONAVIR (MICRO LABS) APPROVAL= AP YEAR= 2025